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PhD position in the Blue Brain Project, Ecole Polytechnique Federale de Lausanne (EPFL)

by Ramaswamy Srikanth

----------------------------------------------------------------------------- PhD position in the Blue Brain Project - Department of In Silico Neuroscience ----------------------------------------------------------------------------- Project title: Digital Reconstruction of Cholinergic Neuromodulation of Neocortical Microcircuitry Supervisors: Dr. Srikanth Ramaswamy, Prof. Henry Markram Keywords: Neocortex, microcircuits, simulation, neuromodulation, acetylcholine, dendrites, synaptic transmission, network activity Project description: Neuromodulators are chemical messengers - hormones, neuropeptides, and neurotransmitters - that diffusely target neurons and synapses in specific brain regions. Distinct groups of neurons located in subcortical areas release neuromodulators such as acetylcholine (ACh), noradrenaline, serotonin, dopamine, and histamine. These neuromodulators directly control information processing in neocortical microcircuits by modulating shifts between activity states such as sleep and wakefulness, or distraction and attention. Neuromodulators are also directly implicated in a spectrum of debilitating disorders such as migraine, schizophrenia, Alzheimer’s and Parkinson’s disease. Yet, despite their crucial role in physiology and pathology, we lack a detailed understanding of the way they regulate the function of dendrites, synapses, neurons, and network activity in neocortical microcircuitry. The objective of the proposed PhD project will be to devise, implement and study biophysical models of ACh neuromodulation of neocortical microcircuitry. The project will leverage the Blue Brain Project’s data-driven digital reconstruction of neocortical microcircuitry1, 2, and augment it with biophysical models of the anatomy and physiology of ACh neuromodulation of somatosensory cortex. Specifically, the project will implement and constrain cellular and synaptic models of ACh neuromodulation and study its regulation of cortical activity states. The project requires active collaboration with the Laboratory of Neural Microcircuitry (LNMC), EPFL to design neurophysiological experiments in thenrodent somatosensory syetem and integrate relevant data into the digital reconstruction. Significant computing resources on a large high performance computing system will be made available for this project. 1. Markram, H.*, Muller, E.*, Ramaswamy, S.*, Reimann, M.* et al. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:2, 456-495. * Co-first author. 2. Ramaswamy S.*, Courcol J-D.*, Abdellah M., Adaszewski S.R., Antille N. et al. (2015). The Neocortical Microcircuit Collaboration Portal: A Resource for Rat Somatosensory Cortex. Front. Neural Circuits 9:44. *Co-first author. Key collaborators: Dr. Rodrigo Perin (EPFL-LNMC), Ms. Ayah Khubieh (EPFL-LNMC), Dr. Eilif Muller (EPFL-BBP), Dr. Fabien Delalondre (EPFL-BBP), Prof. Felix Schürmann (EPFL-BBP), and Prof. Idan Segev (Hebrew University, Jerusalem). This project is offered in the context of the EPFL Doctoral School in Neuroscience (EDNE). Please visit http://phd.epfl.ch/neuroscience-openings for further details, and information on how to apply. Application Deadline: Nov 15th, 2016. For further details on the project contact: Dr. Srikanth Ramaswamy <srikanth.ramaswamy(a)epfl.ch<mailto:srikanth.ramaswamy@epfl.ch>> ------------- Dr. Srikanth Ramaswamy EPFL - Blue Brain Project Biotech Campus Chemin des Mines 9 1202 Geneva Switzerland Tel: +41 21 693 9633 Fax: +41 21 693 5350 www: https://people.epfl.ch/srikanth.ramaswamy

Nov. 10, 2016

Simons-Berkeley Research Fellowship - Call for Applications

by Bruno Olshausen

Simons-Berkeley Research Fellowship -- Call for applications In Spring 2018 the Simons Institute for the Theory of Computing will hold a semester-long program on Brain and Computation, see https://simons.berkeley.edu/programs/brain2018 The Institute invites applications for Simons-Berkeley Research Fellowships in connection this program. Simons-Berkeley Research Fellowships are intended for exceptional young scientists (within at most six years of the award of their PhD at the start of 2017-18 academic year). Applicants who already hold junior faculty or postdoctoral positions are welcome to apply. In particular, applicants who hold, or expect to hold, postdoctoral appointments at other institutions are encouraged to apply to spend one semester as a Simons-Berkeley Fellow subject to the approval of the postdoctoral institution. The Institute expects to award about 30 Fellowships in 2017-18; the majority of these are for one semester, but several appointments for a full academic year are expected to be made. In each semester of residence each Fellow will normally participate in at least one of the ongoing programs at the Institute. The Simons Institute for the Theory of Computing is a major international venue for collaborative research in theoretical computer science and related fields. The Institute is housed on the UC Berkeley campus, and provides a vibrant and welcoming environment for visiting researchers. In each academic semester the activities of the Institute are largely focused on specific research programs, each of which attracts around sixty long-term participants ranging from senior scientists to graduate students. Salaries and benefits are competitive and assistance with visas and housing will be provided. The Institute particularly encourages applications from women and minority candidates. For more on the Simons Institute and application instructions for the Simons-Berkeley Research Fellowships, please see https://simons.berkeley.edu/fellows2017 The deadline for receipt of complete application materials (except letters) is December 15, 2016. --------------------------------------- Bruno A. Olshausen Helen Wills Neuroscience Institute & School of Optometry Director, Redwood Center for Theoretical Neuroscience UC Berkeley 575A Evans hall, MC 3198 Berkeley, CA 94720-3198 http://redwood.berkeley.edu/bruno

Nov. 10, 2016

Neural Processing Letters: 2nd CFP for the Special Issue on "Off the mainstream: advances in neural networks and machine learning for pattern recognition"

by Friedhelm Schwenker

2nd Call for Papers Special issue on Off the mainstream: advances in neural networks and machine learning for pattern recognition to be published in Neural Processing Letters *** Submission deadline: January 31, 2017 *** Guest editors: Edmondo Trentin, University of Siena, Italy (trentin(a)dii.unisi.it) Friedhelm Schwenker, University of Ulm, Germany (friedhelm.schwenker(a)uni-ulm.de) Nemat El Gayar, Cairo University, Egypt (elgayar.neamat(a)gmail.com) Hazem M. Abbas, Ain Shams University, Egypt (hazem.abbas(a)eng.asu.edu.eg) Aims and scope of the special issue: "Mainstream science is about publishing what everyone else is publishing with very small changes. You'd better at least start off that way if you want to get tenure," the sociologist Rodney Stark said. But "big ideas don't come to those who avoid risk", as John Bohannon added. The area of artificial neural networks (ANN) and machine learning (ML) makes no exception to these ends: Mainstream topics, originally stemming from exciting breakthroughs (the "big ideas") that gradually become trends and end-up being mostly over-beaten publishing tracks, have characterized the scientific literature throughout the whole history of these research fields. A few, widely known instances of such (more or less recent) mainstream trends are: - Supervised support vector machine training (in both primal and dual) - Supervised multilayer perceptron training via regular backpropagation - Radial basis functions networks - Bayesian networks (either shallow or deep) - Deep feed-forward and convolutional neural networks - Countless applications of the aforementioned machineries - The “approximation capabilities” of such machineries Based on these premises, this special issue invites paper submissions on real novel research developments in the areas of neural networks and learning machines that (1) are rooted in (or, aimed at) pattern recognition (PR), and that, above all, (2) do not follow in the footsteps of nowadays established trends. Preference (over applications, theoretical analysis, and variants of established techniques) will thus be given to submissions that hand out fresh and innovative ideas/architectures/algorithms, even if they are in their infancy (e.g., possibly lacking of a complete investigation of their theoretical properties). A detailed list of topics of interest would contradict the very perspective of the present special issue. Nonetheless, some general, topical research directions are (to name a few): - New ANN or ML architectures - New ANN, ML, or PR algorithms - New estimation/optimization/assessment techniques for ANNs, ML, or PR - New and sound combination/hybridization of machines - Solutions to new, relevant PR-related problems - New and sound solutions to established PR-related problems If you are not sure on whether your manuscripts matches the aims and scope of this special issue or not, do not hesitate to get in touch with the guest editors at any time. The special issue will comprise (a) papers submitted in response to this call, and (b) extended versions of selected papers from the ANNPR 2016 Workshop (https://neuro.informatik.uni-ulm.de/ANNPR2016/) sponsored by the International Association for Pattern Recognition. Paper submission: Papers must be submitted online via the Neural Processing Letters website (https://www.editorialmanager.com/nepl/default.aspx) selecting the choice that indicates this special issue (identifier: S.I.:Off_mainstream). Prepare your paper following the Journal guidelines for Authors (http://www.springer.com/computer/ai/journal/11063?detailsPage=pltci_1060677) All submitted papers will undergo a regular peer-review process. Important dates: Opening of electronic submission: September 1, 2016 Submission deadline: January 31, 2017 Completion of 1st round of review process: March 31, 2017 Re-submission of revised manuscripts: May 15, 2017 Final decision: June 30, 2017 Tentative publication of the Special Issue: Fall 2017 -- PD Dr. Friedhelm Schwenker University of Ulm Institute of Neural Information Processing D-89069 Ulm, Germany phone: +49-731-50-24159 fax: +49-731-50-24156 email: friedhelm.schwenker(a)uni-ulm.de www: http://www.uni-ulm.de/in/neuroinformatik/mitarbeiter/f-schwenker.html

Nov. 9, 2016

Video course on understanding higher cognition in terms of brain anatomy and physiology

by Andrew Coward

A 29 lecture video course on approaches to understanding cognitive processes in terms of brain anatomy and physiology is now available at www.understandinghighercognition.com<http://www.understandinghighercognition.com> The lectures are based on a course given to third year and graduate students in computer science, psychology and neuroscience at the Australian National University in Canberra and also at Simon Fraser University in Vancouver, Canada. Topics covered include: - The nature of understanding: lessons from the computer science approach to understanding complex systems - Major cognitive phenomena: attention; different types of memory; speech and consciousness - Key topics in brain anatomy, physiology and chemistry - Practical pressures on brain architecture exerted by natural selection: resource limits, learning without interference with prior learning, etc; - Architectural forms resulting from the practical pressures - Evidence for the existence of the predicted architectural forms in the brain; how to use the forms to support understanding - Understanding attention and different types of memory: semantic, episodic, priming, working and procedural memory - Understanding specific cognitive tasks - Understanding human consciousness and self awareness. Each lecture is divided into 5 - 10 minute topic videos. Lecture format is mainly images and graphics supported by verbal explanations. Textbook for the course is "Towards a Theoretical Neuroscience: from Cell Chemistry to Cognition<http://www.springer.com/us/book/9789400771062>" <http://www.springer.com/us/book/9789400771062> published by Springer. Access to the lectures is free.

Nov. 7, 2016

Post-Doctoral Position to Research Mediating and Moderating Factors that Determine Transfer of Working Memory Training at UC Riverside and UC Irvine.

by Aaron Seitz

Please forward the below to anyone that you think might be interested. Thanks, -Aaron Post-Doctoral Position to Research Mediating and Moderating Factors that Determine Transfer of Working Memory Training at UC Riverside and UC Irvine. Aaron Seitz (UCR) and Susanne Jaeggi (UCI) are seeking to hire a post-doctoral researcher to work on a project funded by the National Institute of Mental Health entitled ³The Understanding Mediating and Moderating Factors that Determine Transfer of Working Memory Training² (https://ucrtoday.ucr.edu/40627 <https://ucrtoday.ucr.edu/40627> ). This individual is expected to take a lead role in designing and conducting experimental work investigating features of training that differentially lead to learning and transfer of learning, participant characteristics that determine predispositions for different training outcomes, and develop and implement tests that are valid towards assessing potential far transfer of working memory training to ecological settings. This project, which intends to run 31,000+ research participants (online and in lab) on working memory training, aims to generate a robust and reliable dataset on Working Memory training to settle current debates in the field and translate these findings to promote more effective methods of cognitive rehabilitation. Successful candidates should have strong technical skills, management skills, creativity and perseverance required to play a lead role in this sizeable project, and have expertise in one or more of the following areas and knowledge of the others; working memory, cognitive training, perceptual learning, and methods of assessing individual differences and effects of interventional studies. Researchers must possess a doctoral degree in Psychology, Education, Cognitive Science, Neuroscience, or a related field. The University of California offers excellent benefits. Salary is based on research experience. The initial appointment is for 1 year with a possibility of extension. The post-doctoral researcher will be involved at all stages of the proposed research, including setting up experiments, collecting and analyzing data, training and supervision of graduate students and undergraduate research assistants, and dissemination of results at conferences and in research publications. The postdoc will spend equal time on the UCR and UCI campus and work closely with both Seitz and Jaeggi to insure that procedures are coordinated between the sites and that all personnel are properly trained and supervised. The primary appointment will be at the UC Riverside Brain Game Center for Mental Fitness and Well-being (http://braingamecenter.ucr.edu/ <http://braingamecenter.ucr.edu/> ). The Brain Game Center¹s mission is to research, test, and disseminate evidence-based, scientifically optimized brain fitness games that transfer benefits to real-life activities. The Center has recently moved into a 3000 square foot facility that provides an ideal environment for the proposed work with a staff of full time research coordinators, full time programmers and a team of postdocs, graduate students, and an army of research assistants that facilitates the development, testing and dissemination of brain training games and cognitive assessment tools. The Brain Game Center is the only university-based research center focused on research of brain training games, and it has a track record of making tested procedures publically available so that people can try them out for themselves. The post-doc will also spend time at the UCI Working Memory and Plasticity Lab (http://wmp.education.uci.edu <http://wmp.education.uci.edu/> ) whose mission lies in the development of working memory interventions for populations across the lifespan, with the aim to understand the underlying cognitive and neural mechanisms that drive training-related changes using behavioral and neuroimaging methods, as well as transcranial electrical stimulation. The WMP lab currently employs 3 full-time research coordinators, as well as a team of undergraduate research assistants, and graduate students from both, the School of Education and the Department of Cognitive Sciences, and there is a host of ongoing national and international research collaboration providing opportunities for networking and intellectual exchange. Candidates should send a cover letter, CV, relevant publications, and the names of three references with phone numbers and email addresses to: Aaron Seitz aseitz(a)ucr.edu <mailto:aseitz@ucr.edu> ) and/or Susanne Jaeggi (susanne.jaeggi@u <mailto:susanne.jaeggi@gmail.com> ci.edu <http://ci.edu/> ). Review of materials will begin immediately and will continue until the position is filled. ************************************************** Aaron Seitz, Ph.D. Professor of Psychology Director of UCR Brain Game Center University of California, Riverside 900 University Ave. Riverside, CA 92521 Ph: (951) 827-6422 Fax: (951) 827-3985 Email: aseitz(a)ucr.edu Web: http://faculty.ucr.edu/~aseitz/ BGC: http://braingamecenter.ucr.edu **************************************************

Nov. 5, 2016

2 postdoctoral positions at the University of Pennsylvania

by Maria Neimark Geffen

2 postdoctoral positions: Neuronal circuits for dynamic auditory perception. The Geffen Laboratory at the University of Pennsylvania (Philadelphia, PA, USA) has two openings for a postdoctoral researcher (one experimental and one theoretical/computational) to study the neuronal circuits for dynamic auditory perception. There are a number of projects available, including: investigating intra-cortical and subcortical circuits supporting auditory adaptation; identifying neuronal circuits for hearing in the presence of noise; unraveling neuronal circuits controlling learning-driven changes in auditory acuity. We use cutting-edge experimental techniques for investigating population neuronal activity, including two-photon imaging of Calcium activity in behaving, head-fixed rodents, large-scale electrophysiological chronic and acute recordings, optogenetic, pharmacological and behavioral techniques. We are a creative, productive and collaborative group. Please see our lab website for more details on ongoing projects in the laboratory and recent publications ( http://www.med.upenn.edu/hearing <http://www.med.upenn.edu/hearing> ). The ideal candidate will be an energetic, talented, friendly, enthusiastic and creative researcher, who has recently completed (or plans on completing) their PhD and has received training in neuroscience, psychology, chemistry or biology (for the experimental position) or computational neuroscience, physics, mathematics or computer science (for the computational position). Prior experience in systems neuroscience is desired, but a highly successful applicants wishing to switch to neuroscience from other fields will also be considered. Proficiency with Matlab or other scientific computing software is expected. The campus of the University of Pennsylvania <http://www.upenn.edu/> has a wonderful collegiate feel, and the Medical School is located on the main campus, facilitating collaborations across departments. For a sample of events that almost everyone in our lab attends, consider: a weekly lab meeting, a weekly Computational Neuroscience Initiative seminar, a bi-weekly auditory journal club, a weekly interdisciplinary Mind and Brain seminar, and much more. Philadelphia is a vibrant city with a variety of cultural, gastronomical and entertainment attractions. To apply, please send your CV along with a cover letter briefly summarizing your research interests and include pdfs of your recent publications to Prof. Maria N. Geffen mgeffen(a)med.upenn.edu <mailto:mgeffen@med.upenn.edu> .

Nov. 3, 2016

Visit the Bernstein Network at booth #4017 at SfN 2016 for your next career step in Computational Neuroscience

by Kerstin Schwarzwaelder

Dear all, The Bernstein Network Computational Neuroscience will exhibit at the SfN Meeting 2016. Please find us at the "Neuroscience in Germany" booth #4017. The booth will present: * research fields * study and training programs * open positions * research and funding opportunities We are looking forward to welcoming you at booth #4017! Best regards, Kerstin Schwarzwälder -- Dr. Kerstin Schwarzwälder Scientific Coordination / Management Officer Please note: Our email addresses have changed. Please use k.schwarzwaelder(a)fz-juelich.de<mailto:k.schwarzwaelder@fz-juelich.de> Bernstein Network Computational Neuroscience | Bernstein Coordination Site (BCOS) Branch Office of the Forschungszentrum Jülich at the University of Freiburg Hansastr. 9A | 79104 Freiburg, Germany phone: (+49) 0761 203 9589 mail: k.schwarzwaelder(a)fz-juelich.de<mailto:k.schwarzwaelder@fz-juelich.de> web: www.nncn.de<http://www.nncn.de> Twitter: NNCN_Germany<https://twitter.com/NNCN_Germany> YouTube: Bernstein TV<https://www.youtube.com/user/BernsteinNetwork> Facebook: Bernstein Network Computational Neuroscience, Germany<https://www.facebook.com/BernsteinNetwork/> LinkedIn: Bernstein Network Computational Neuroscience, Germany<https://www.linkedin.com/company/bernstein-network-computational-neuroscien…> <https://www.linkedin.com/company/bernstein-network-computational-neuroscien…> ------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------ Forschungszentrum Juelich GmbH 52425 Juelich Sitz der Gesellschaft: Juelich Eingetragen im Handelsregister des Amtsgerichts Dueren Nr. HR B 3498 Vorsitzender des Aufsichtsrats: MinDir Dr. Karl Eugen Huthmacher Geschaeftsfuehrung: Prof. Dr.-Ing. Wolfgang Marquardt (Vorsitzender), Karsten Beneke (stellv. Vorsitzender), Prof. Dr.-Ing. Harald Bolt, Prof. Dr. Sebastian M. Schmidt ------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------

Nov. 3, 2016

3 Research fellow positions at the University of Sussex

by Thomas Nowotny

We have 3 open positions for research fellows in Computational Neuroscience, bio-inspired Robotics and Computer Science (GPU accelerated computing). The positions are part of the new Brains-on-Board project (http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/P006094/1) which is a multi-university collaboration aiming to create robotic controllers that will enable autonomous robots with the navigational and learning abilities of a honeybee. The project involves five research groups at the University of Sheffield, Queen Mary University, London, and the University of Sussex performing research whose goal is biomimetic robot control and which will combine autonomous robotics, computational neuroscience, accelerated neural network simulations on GPU architectures and insect neuroscience and behaviour. In Sussex we are seeking to employ a team of 3 research fellows for initially 2 years, with possible extension up to 5 years. We envisage the fellows to start in January 2017. RF 1 (ref 1388) in bio-inspired robotics, will develop insect-derived models of navigation and apply them to autonomous robots. The work will include refining and developing models of insect navigation and testing them on robotic platforms ranging from the Sussex Gantry robot through wheeled robots to autonomous aerial vehicles. A successful candidate will have a keen interest in the interface of computational biology and bio-inspired robotics and a proven track record in working in this area. RF 2 (ref 1389) in Computational Neuroscience, will work on models of associative learning, multimodal integration and decision making in insects. The work will include formulating neuronal network models of the mushroom bodies, central complex and motor areas of the bee brain constrained by experimental data. The models will then be employed and tested on robotic platforms, including wheeled robots and aerial vehicles. A successful candidate will have a keen interest in computational neuroscience and experience with computational modelling. RF 3 (ref 1390) in Computer Science, working on GPU accelerated simulation of brain models and brain-inspired robot controllers, building on our GeNN meta-compiler and the SpineCreator/SpineML API to GeNN. The work will include developing methods for model- and hardware-aware GPU-accelerated simulations methods that will allow us to efficiently simulate both large-scale models in Computational Neuroscience on super-computers and bio-inspired robotic controllers on embedded systems GPU accelerators. A successful candidate will have proven skills in complex software development with a focus on scientific computing. All RFs will work together on the project within Sussex and in the larger Brains-On-Board team. We encourage applicants to apply for multiple positions if they are interested and feel qualified. Please indicate any preferences when applying for multiple positions. In order to apply got to http://www.sussex.ac.uk/aboutus/jobs/1388-1389-1390 where you can find further details and the application form. The closing date is 1 December 2016. For informal enquiries, please contact Prof Thomas Nowotny (t.nowotny(a)sussex.ac.uk<mailto:t.nowotny@sussex.ac.uk>) or Dr Andy Philippides (andrewop(a)sussex.ac.uk<mailto:andrewop@sussex.ac.uk>). With kind regards, Thomas -- Prof Thomas Nowotny Director of Research and Knowledge Exchange School of Engineering and Informatics University of Sussex Falmer, Brighton BN1 9QJ, UK Phone: +441273678593 FAX: +441273877873

Nov. 2, 2016

PhD position @ Blue Brain Project - Plasticity in the neocortex

by emuller

----------------------------------------------------------------------------- PhD position in the Blue Brain Project - Department of In Silico Neuroscience ----------------------------------------------------------------------------- Project title: Principles of biophysical structural plasticity in the neocortex Supervisors: Prof. Henry Markram, Dr. Eilif Muller Keywords: simulation, neocortex, plasticity, network reorganization, assemblies, coding, dendrites, calcium, NMDA Project description: During our lifetimes, our brains undergo continuous changes as a consequence of our experiences. Synaptic plasticity—the biological process by which brain activity leads to long-term changes in synaptic connections—is thought to be central to learning and memory. However, little is known about how this process shapes the specialization of biological neural networks, such as the neocortex. The objective of the present work will be to devise, implement and study data-driven biophysical models of synaptic and structural plasticity for the formation of functional neocortical networks. This project will leverage the Blue Brain Project data-driven reconstruction of a neocortical microcircuit [1], and augment it with data-driven biophysical calcium-based models of synaptic and structural plasticity. The specific objective of this PhD project will be to implement and constrain models of structural plasticity, and study the formation of assemblies, and emergent structure-function relationships in the presence of structured input. The prospective student will join an ongoing collaboration including international experts in biophysical modeling of plasticity and dendrites, topological analysis of network structure, and optimization of neural simulations for large supercomputers. A significant allocation of computing time on a large HPC system will be at the disposal of this project. [1] Markram, H., Muller, E., Ramaswamy, S., Reimann, M. et al. Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:2, 456-495 (2015). Key external collaborators: Dr. Michael Graupner (CNRS, Université Paris Descartes), Prof. Idan Segev (Hebrew University Jerusalem) This project is offered in the context of the EPFL Doctoral School in Neuroscience (EDNE). Please visit http://phd.epfl.ch/neuroscience-openings for further details, and information on how to apply. Application Deadline: Nov 15th, 2016. For further details on the project contact: Dr. Eilif Muller <eilif.mueller(a)epfl.ch> ------------- Dr. Eilif Muller Section Manager - In Silico Neuroscience - Experimentation EPFL - Blue Brain Project Biotech Campus Chemin des Mines 9 1202 Geneva Switzerland Tel: +41 21 693 0698 Fax: +41 21 693 5350 www: http://bluebrain.epfl.ch/page-77926-en.html www: http://neuralensemble.org/people/eilifmuller

Nov. 2, 2016

Fully funded postdoc position at the University of Geneva

by Jolivet, Renaud

The University of Geneva seeks one postdoc in computational neuroscience to investigate the relation between information transfer at synapses and in neural networks, and concomitant energy consumption. The starting date is May 2017. This position is fully funded by the Swiss National Science Foundation for 24 months. Initial appointment is for one year. Research will be conducted in the medical physics group of the physics section at the University of Geneva, under the supervision of Prof. Renaud Jolivet. * Summary Information transmission in the brain is energetically expensive, yet has to satisfy demands of speed and signal-to-noise reliability. We have recently shown that the strong retinogeniculate synapse relaying information from the retina to the thalamus resolves these competing constraints by maximizing energetic efficiency when transferring information. In their physiological state, these synapses are not set to transmit the maximum amount of information possible: information transmission increases when larger excitatory postsynaptic currents (EPSCs) are injected into the postsynaptic thalamic neuron. However, EPSCs that are larger or smaller than physiological EPSCs decrease the information transmitted per energy used. The physiological EPSC size therefore maximizes energy efficiency rather than pure information transfer across the synapse. In other words, the retinogeniculate synapse trades information for energy savings (http://dx.doi.org/10.1016/j.cub.2015.10.063; http://dx.doi.org/10.1016/j.neuron.2012.08.019) These findings suggest maximization of information transmission per energy used as a design principle in the brain. However, it is unclear how broadly this principle applies. Whether energy efficiency at excitatory synapses is a special property of strong relay synapses, or a more general principle also governing synaptic inputs that contribute more weakly to determining the output of the postsynaptic cell is an open question. These findings also raise the question of what mechanisms are in effect in order to achieve energetic efficiency of information transfer at synapses. This project will address these questions using information theory and simulations of biologically validated neuron models. Applicants must imperatively be self-sufficient programmers (MATLAB preferred) and have a strong background in computational neuroscience. They should be familiar with several of the following topics: information theory, Hodgkin-Huxley models, the NEURON simulation environment, signal processing, models of synaptic plasticity, models of neural networks. Please contact renaud.jolivet(a)unige.ch<mailto:renaud.jolivet@unige.ch> for additional information. * About the University of Geneva (UNIGE) UNIGE is a generalist French-speaking university located in Geneva, Switzerland. The QS World University Rankings 2016 and Times Higher Education World University Rankings 2016/17 respectively rank UNIGE as 95th and 131st worldwide. It ranks 41st worldwide for science (Shanghai Academic Ranking of World Universities in Natural Sciences and Mathematics 2016). It is Switzerland’s second largest university with more than 17000 students of 150 different nationalities and about 4000 researchers of 113 nationalities, who study and work in 9 different faculties. UNIGE trains a large number of PhD students and postdocs in neuroscience. The various research and teaching activities are listed at http://neurocenter.unige.ch/ and at https://www.unil.ch/ln/en/home.html. UNIGE is also developing with other institutions a new campus in Geneva (http://www.campusbiotech.ch/en/) focusing heavily on neuroscience and translational research. Geneva is at the heart of a conurbation with more than 1.25 million inhabitants. It is a global city, a financial center, and worldwide center for diplomacy and research. It has one of the highest quality of life in the world. It offers varied cultural activities and outdoor opportunities being located at one extremity of Lake Geneva, one of the largest lakes in Europe, on the western doorstep of the Alps. The University of Geneva offers competitive salaries and conditions at all levels in a young, dynamic, and multicultural environment. It is an equal opportunity employer and women are encouraged to apply. The official language of the laboratory is English. * How to apply Please send an e-mail to renaud.jolivet(a)unige.ch<mailto:renaud.jolivet@unige.ch> with your resume, list of publications, a one-page statement describing your research interests and career plan, and the names of at least three references. — Prof. Renaud Jolivet CERN, Experimental Physics Department & University of Geneva, Physics Section +41 22 767 24 70 (CERN) +41 22 379 62 75 (UNIGE) +41 79 830 21 29 (mobile) renaud.blaise.jolivet(a)cern.ch<mailto:renaud.blaise.jolivet@cern.ch> https://sites.google.com/site/renaudjolivet/

Nov. 1, 2016