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Graduate studies in comp.life.sci: comp.neuro, sys.bio, networks, appl.math, bioinf ... Jacobs University, Germany

by Jens Christian Claussen

Invitation for a NEW study program in Computational Life Science in Bremen, Germany Jacobs University Bremen, Germany, welcomes (late) applications (EU citizens or holders of visa for Germany or a EU country only) for the new graduate program (MSc and integrated PhD): http://www.jacobs-university.de/complife-graduate-program For best consideration, please do apply until June 15, latest mid-July, with the usual documents, and a letter/essay of motivation, and be prepared to select one research group for the first lab rotation, see the group pages: http://www.jacobs-university.de/comp-life-graduate-program/complife-groups with the research directions of the core faculty research areas: Computational Neuroscience Bioinformatics Medical Imaging Computational Systems Biology Theoretical Physics Ecological Modeling Mathematics Mathematical Modeling of Medical Processes If you already hold a Master of Science degree in a relevant discipline, and you apply for iPhD track only, please get also in touch with a group leader (in parallel to your application) as all PhD positions are funded within the groups. Applications for CompLife and for the current Computational Biology Branch of MoLife will be handled equivalently this year, so a double application is not necessary. The extended launch of the CompLife program will be for Fall 2015 - stay tuned! We offer reduced study fees for highly skilled applicants! In addition, there may be a small number of departmental stipends available (competitive, apply asap!). Jacobs University is a great international and renowned place for study and research. We warmly welcome applications from all countries (currently students are from 100+ countries)! Looking forward to your application! With best regards, Jens Christian Claussen -- PD Dr. Jens Christian Claussen j.claussen(a)jacobs-university.de Systems Biology Lab - Jacobs University Bremen +49-421-2003240 http://sysbio.jacobs-university.de/website/claussen http://jclaussen.user.jacobs-university.de/ http://webmail.inb.uni-luebeck.de/%7Eclaussen/ Networks, Physics, Socioeconomic Systems? http://www.dpg-physik.de/dpg/gliederung/fv/soe/index.html MSc in Computational Life Science? PhD in Systems Biology? Go here: http://www.jacobs-university.de/ses/complife

June 11, 2014

PhD position, computational neuroimaging, Dresden/Germany

by Stefan Kiebel

Dear all, Please find attached an advert for a PhD position. The position is ideal for someone who would like to work at the interface between computational modelling and neuroimaging experiments. With best wishes, Stefan Kiebel --------- The Department of Psychology, Institute of General Psychology, Biopsychology and Methods of Psychology, Chair of Neuroimaging (Prof. Dr. Stefan Kiebel) invites applications for a Member of academic staff / PhD student (E 13 TV-L) with 50 % of the fulltime weekly hours. The position will start (ideally) on 01.10.2014. The PhD position is initially limited for 3 years. A contract extension for a fourth year is possible. The period of employment is governed by the Fixed Term Research Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG). The main research goal is the development and experimental testing of novel computational models of decision making. The computational models typically employ Bayesian inference and experiments are performed using fMRI and EEG. The Chair of Neuroimaging has full access to all experimental facilities at the Neuroimaging Center at the TU Dresden. The Neuroimaging Center is equipped with a research-only MRI scanner (Siemens 3T TIM Trio), MRI-compatible EEG and eye tracking, and a transcranial magnetic stimulation (TMS) unit. All experimental facilities are supported by experienced physics and IT staff. For computational work, the group has access to the TU Dresden high-performance computing clusters. The Chair of Neuroimaging will be newly established at the TU Dresden, and will move from the Max Planck Institute in Leipzig (http://www.cbs.mpg.de/depts/n-3/dyn/@@index.html) to Dresden. Tasks: The PhD student will work on a series of projects in the area of decision making using computational modelling of behavioural and neuroscientific data. Requirements: The candidate should have either (i) a university degree in psychology or cognitive neuroscience and a strong interest in computational modeling, or (ii) a university degree in mathematics, computational neuroscience, physics, or similar with a strong interest in performing neuroimaging experiments for testing computational models. The position is ideal for candidates interested in research at the interface between computational modeling and experimental neuroimaging. For questions or an informal discussion about this position please contact Prof. Stefan Kiebel (stefan.kiebel(a)tu-dresden.de) Applications from women are particularly welcome. The same applies to people with disabilities. Applicants should send their application documents (cover letter including a brief description of personal qualifications and future research interests, CV and contact details of two personal references) until 07.07.2014 (stamped arrival date of the university central mail service applies) - preferentially via e-mail as a single PDF-file - to julia.herdin(a)tudresden.de (Please note: We are currently not able to receive electronically signed and encrypted data.) or to TU Dresden, Fakultät Mathematik und Naturwissenschaften, Fachrichtung Psychologie, Institut für Allgemeine Psychologie, Biopsychologie und Methoden der Psychologie, Professur für Neuroimaging, Herrn Prof. Dr. Stefan Kiebel, 01062 Dresden. -- Stefan Kiebel, Ph.D. Professor of Neuroimaging Dept of Psychology Technical University Dresden, Germany Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany http://www.cbs.mpg.de/~kiebel

June 11, 2014

Posdoc job opening in Computational/Systems Neuroscience

by Chen, Zhe

Postdoctoral Fellow in Systems/Computational Neuroscience New York University School of Medicine New York, NY Applications are now being accepted for a postdoctoral fellow position to combine computational and experimental techniques to study the neural mechanism of attention of thalamus-neocortical circuits using a healthy or diseased rodent model. The applicant will work closely with Dr. Zhe (Sage) Chen and Dr. Mike Halassa at the New York University School of Medicine, with cross-disciplinary training in computational and systems (experimental) neuroscience, including rodent behavior and electrophysiology. The applicant will have great opportunities to interact with a large and growing neuroscience community at the NYU campus, including the Neuroscience Institute (http://neuroscience.med.nyu.edu<http://neuroscience.med.nyu.edu/>), Center for Neural Science (http://www.cns.nyu.edu<http://www.cns.nyu.edu/>), Department of Neuroscience & Physiology (http://neuro-physio.med.nyu.edu<http://neuro-physio.med.nyu.edu/>), and Department of Psychiatry (http://psych.med.nyu.edu<http://psych.med.nyu.edu/>). This position is available from September 2014, and will be funded for two years and renewable. Applications must have a PhD degree in Neuroscience, Engineering (Biomedical or Electrical), Statistics, Physics, or a related discipline. The desired applicant is expected to be highly motivated and work independently as well as cooperatively with other colleagues in the research projects. Ability to learn new techniques and resolve new research challenges is essential. Previous training in some areas, such as neural data analysis, computational neuronal modeling, computer programming (MATLAB/Python/C), neural interfaces, optogenetics, in vivo neural recordings at the system levels, is preferred. Research experience with rodent neural circuits is a plus. To apply, please send an email along with (i) curriculum vitate; (ii) a cover letter describing research accomplishments and interests; (iii) the names and contact information of two to three references to: Dr. Zhe (Sage) Chen (zhe.chen3(a)nyumc.org<mailto:zhe.chen3@nyumc.org>) or Dr. Mike Halassa (michael.halassa(a)nyumc.org<mailto:michael.halassa@nyumc.org>) with a subject line “Postdoc application”. ------------------------------------------------------------ This email message, including any attachments, is for the sole use of the intended recipient(s) and may contain information that is proprietary, confidential, and exempt from disclosure under applicable law. Any unauthorized review, use, disclosure, or distribution is prohibited. If you have received this email in error please notify the sender by return email and delete the original message. Please note, the recipient should check this email and any attachments for the presence of viruses. The organization accepts no liability for any damage caused by any virus transmitted by this email. =================================

June 10, 2014

Graduate studies in the neuroscience of spatial motion estimation and motor planning

by Andrea Green

Graduate studies in the neuroscience of spatial motion estimation and motor planning Département de Neurosciences, Université de Montréal Applications are invited for doctoral and postdoctoral studies in systems neuroscience in the laboratory of Dr. Andrea Green. The successful applicant will join a multidisciplinary research group studying how the brain integrates multisensory cues to create estimates of our spatial motion and how such estimates are used for perception and motor planning. Research in my laboratory involves computational models of the nervous system, behavioral and neural recording experiments in non-human primates as well as human behavioral studies. Depending on the applicant's qualifications and interests, they will help to design and conduct behavioral and/or neurophysiological experiments, analyze data, develop theoretical models of neural systems, prepare manuscripts for publication, and participate in international conferences. While students with a strong background in biological sciences, engineering, mathematics, or computer science, are particularly encouraged to apply, all motivated students with an interest in understanding the brain will be considered. The successful applicant will receive a competitive salary in accordance with university guidelines. For further information, please contact Dr. Andrea Green (andrea.green(a)umontreal.ca) Applicants are asked to submit a curriculum vita, a transcript of previous studies, and the contact information for two references to: Dr. Andrea Green andrea.green(a)umontreal.ca Tel: 514-343-6111 x3301 Département de Neurosciences, Université de Montréal C.P 6128 Succursale Centre-Ville Montréal, QC H3C 3J7, CANADA Applications will be accepted until the positions are filled.

June 10, 2014

Reminder: Valentino Braitenberg Award for Computational Neuroscience - Call for Nominations

by Kerstin Schwarzwälder

Dear Colleagues, Please let me remind you that the Bernstein Association for Computational Neuroscience <http://www.nncn.de/en/bernstein-association> invites nominations for the *Valentino Braitenberg Award for Computational Neuroscience.* The award is biannually presented by the Bernstein Association to a scientist in recognition of outstanding research that contributes to our understanding of the functioning of the brain. The major criterion for the award is the impact or potential impact of the recipient's research on the field of brain science. In the spirit of Valentino Braitenberg's research, special emphasis is given to theoretical studies elucidating the functional implications of brain structures and their neuronal network dynamics. The crucial work should preferentially have been carried out in a European institution. The awardee receives a €5.000 prize donated by the Autonome Provinz Bozen Südtirol as well as complimentary participation (registration, travel, and hotel accomodation) in the Bernstein Conference 2014. Here, the prize is awarded together with a Golden Neuron pin badge in a special ceremony that includes the Valentino Braitenberg lecture given by the awardee. Nominations may be submitted by scientists working in the field of Computational Neuroscience and should include the following documents: * One-page laudation, in which the scientific work of the candidate is honored with regard to the award's criteria * CV and list of publications *Deadline for nominations is June 16, 2014* by e-mail to info(a)bcos.uni-freiburg.de The call for nominations can be found under the following URL: www.nncn.de/en/bernstein-association/valentino-braitenberg-award-for-comput… For inquiries please contact info(a)bcos.uni-freiburg.de Best regards, Kerstin Schwarzwälder -- Dr. Kerstin Schwarzwälder Bernstein Coordination Site of the National Bernstein Network Computational Neuroscience Albert Ludwigs University Freiburg Hansastr. 9A 79104 Freiburg Germany phone: +49 761 203 9594 fax: +49 761 203 9585 schwarzwaelder(a)bcos.uni-freiburg.de www.nncn.de Twitter: NNCN_Germany <http://twitter.com/NNCN_Germany> YouTube: Bernstein TV <http://www.youtube.com/user/BernsteinNetwork> Facebook: Bernstein Network Computational Neuroscience, Germany <https://www.facebook.com/BernsteinNetwork> LinkedIn: Bernstein Network Computational Neuroscience, Germany <http://www.linkedin.com/company/bernstein-network-computational-neuroscienc…>

June 10, 2014

Integrative Brain Function Workshop: Multi-modal approaches to understand brain functions

by Joseph Lizier

Dear All, Please find below details of the Integrative Brain Function Workshop: Multi-modal approaches to understand brain functions, to be held in Melbourne on Monday 30 June. Integrative Brain Function Workshop Multi-modal approaches to understand brain functions The goal of this workshop is to offer an opportunity for neuroscientists with various backgrounds to interact and exchange ideas. Specifically, we encourage participation of neuroscientists who are interested in understanding the neural systems at the perceptual and behavioural level and who try to combine multiple methodologies, such as electrophysiology, imaging, advanced signal processing and computational modelling. Date: Monday June 30, 2014. (from 9am) Deadline for abstracts: June 9 Location: Monash Biomedical Imaging facility, 770 Blackburn Rd, Clayton VIC, Australia. Keynote speaker: David Leopold from NIH/NIMH, USA Cortical circuits underlying social visual perception in the primate brain Speakers: Elizabeth Zavitz (Monash University) Population coding of motion direction in marmoset area MT is rapid and sustained Alex Fornito (Monash University) Mapping the context-dependent organization of large-scale brain networks with fMRI Farshad Mansouri (Monash University) The role frontal pole cortex (area 10) in cognitive flexibility and executive control Ben Fulcher (Monash University) Highly comparative time-series analysis for neuroscience Stefan Bode (University of Melbourne) The application of multivariate pattern classification analysis to fMRI and EEG data Spencer Chen (University of Sydney) Population correlations and spatial discrimination in area MT Dean Freestone (University of Melbourne) Estimation of Functional Dynamics using Data-Driven Mesoscopic Nerual Modeling Rory Townsend (University of Sydney) Detecting spatiotemporal dynamics in primate neural oscillations Joseph Lizier (CSIRO, Sydney) Local active information storage in distributed cortical information processing Steven Petrou (the Florey Institute of Neuroscience and Mental Health) Revealing pathological mechanisms in genetic epilepsy Enquiries please contact Nao Tsuchiya Click here to Register http://www.med.monash.edu.au/psych/research/activities/seminars.html -- ------------------------------------------------------------------------- Nao (Naotsugu) Tsuchiya, Ph.D. 1. Associate Professor School of Psychological Sciences Faculty of Medicine, Nursing and Health Sciences, Monash University 2. ARC Future Fellow homepage: http://users.monash.edu.au/~naotsugt/Tsuchiya_Labs_Homepage/Main.html

June 10, 2014

NEURAL COMPUTATION - July 1, 2014

by Terry Sejnowski

Neural Computation - Contents -- Volume 26, Number 7 - July 1, 2014 Available online for download now: http://www.mitpressjournals.org/toc/neco/26/7 ----- Article Motor Cortex Microcircuit Simulation Based on Brain Activity Mapping George L Chadderdon, Ashutosh Mohan, Benjamin A Suter, Samuel A Neymotin, Cliff C Kerr, Joseph T Francis, Gordon MG Shepherd, and William W Lytton Letters Discovering Functional Neuronal Connectivity From Serial Patterns in Spike Train Data Casey Diekman, Kohinoor Dasgupta, Vijay Nair, and K.P. Unnikrishnan Risk-sensitive Reinforcement Learning Yun Shen, Michael J. Tobia, Tobias Sommer, and Klaus Obermayer On Criticality in High-dimensional Data Saeed Saremi, Terrence J Sejnowski Spiking Neural P Systems With Thresholds Xiangxiang Zeng, Xingyi Zhang, Tao Song, and Linqiang Pan Balanced Crossmodal Excitation and Inhibition Essential for Maximizing Multisensory Gain Osamu Hoshino Universal Approximation Depth and Errors of Narrow Belief Networks With Discrete Units Guido Francisco Montufar Multiple Tests Based on a Gaussian Approximation of the Unitary Events Method With Delayed Coincidence Count Christine Tuleau-Malot, Amel Rouis, Franck Grammont, and Patricia Reynaud-Bouret Intrinsic Graph Structure Estimation Using Graph Laplacian Atsushi Noda, Hideitsu Hino, Masami Tatsuno, Shotaro Akaho, and Noboru Murata Causal Discovery via Reproducing Kernel Hilbert Space Embeddings Zhitang Chen, Kun Zhang, Laiwan Chan, and Bernhard Scholkopf ------------ ON-LINE -- http://www.mitpressjournals.org/neuralcomp SUBSCRIPTIONS - 2014 - VOLUME 26 - 12 ISSUES USA Others Electronic Only Student/Retired $70 $193 $65 Individual $124 $187 $115 Institution $1,035 $1,098 $926 Canada: Add 5% GST MIT Press Journals, 238 Main Street, Suite 500, Cambridge, MA 02142-9902 Tel: (617) 253-2889 FAX: (617) 577-1545 journals-orders(a)mit.edu ------------

June 9, 2014

Method development for coupled EEG-fMRI (2x full EPSRC PhD studentships)

by Etienne B. Roesch

Method development for coupled EEG-fMRI (2x full EPSRC PhD studentships) The goal of the project is to develop novel methods for the joint analysis of signals from electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), when they are obtained concurrently. Technological advances of the last 10 years make it possible for scientists to record both modalities concurrently, in what is now known as coupled EEG-fMRI. By simultaneously recording these two modalities, scientists can potentially say where and when neural activity is occurring, whereas previously researchers had to settle for one or the other. This engineering feat, however, has not yet been met with the ability to make use of the combination of these signals to infer more knowledge than would otherwise be gathered in separate experiments. Filling this gap is the ambition of the present project. This is a method project, which requires skills and knowledge in neuroscience, applied mathematics/statistics/physics and programming. Candidates who have a strong background in at least two of these three fields are encouraged to apply, if they are enthusiastic about the third. Two full studentships are available, and we expect to appoint one candidate who is stronger in empirical work and a second who is stronger in analytics. Candidates are expected to have had some prior exposure to at least one of the two modalities, but will receive training in both. The two students will be supervised by Dr. Etienne Roesch and receive support from Dr. Michael Lindner and Prof. Tom Johnstone, with R&D support from Brain Products, one of the world’s leading manufacturers of MRI-compatible EEG systems. The group led by Dr. Roesch fosters interdisciplinary thinking, and students will have the opportunity to engage in ongoing empirical and modelling work related to perception and action. The Centre for Integrative Neuroscience and Neurodynamics (CINN) is host to a research-dedicated 3T Siemens TRIO, with a full license for sequence development, and a full suite of MR-compatible systems. Additionally, the students will be granted access to the cluster of NVIDIA Tesla GPUs and other facilities at CINN, as well as at the Brain Embodiments Laboratory, in the School of Systems Engineering. The University of Reading is ranked as one of the UK’s 20 most research-intensive universities and as one of the top 200 universities in the world (Times Higher Education 2013). Our campus was voted first in the Times Higher Education Student Experience survey and has a Green Flag Award. It is situated 25 minutes West of London. Reading University Students’ Union was voted the 6th best in the UK (National Student Survey 2012). Essentials: Commitment to academic research and personal development; Ability to work collaboratively; Effective interpersonal and communication skills, including writing to a high standard, document preparation for technical notes and journal papers; Experience of work in interdisciplinary settings; Attention to details. Desirables: Self-guided work in developing statistical designs and approaches in research; Creative approach to problem solving; Ability to work independently; Experience in giving presentations and conveying complex ideas clearly. Eligibility: Applicants should hold a minimum of a UK Honours Degree at 2:1 level or equivalent in a relevant subject. Please note that due to restrictions on the funding this studentship is for UK/EU applicants only. Funding Details: Studentship will cover Home/EU Fees, pay the Research Council minimum stipend (£13,863 in 2014/15) for up to 3 years and include funding for international conferences. How to apply: To apply for this studentship please submit an application for a PhD in Cybernetics (full time) to the University – see http://www.reading.ac.uk/Study/apply/pg-applicationform.aspx . In the section ‘Research proposal’, please upload or copy-paste your covering letter. When prompted as part of your online application, you should provide details of the funding you are applying for, quoting the reference GS14-68. Once you have submitted your application, you should receive an email to confirm receipt of your online application. Please forward this email, along with your covering letter and CV (as pdf), to Dr. Etienne B. Roesch, e.b.roesch(a)reading.ac.uk, by the application deadline. Application Deadline: Monday 14th July 2014 (interviews in August) Further Enquiries: Please contact Dr. Etienne B. Roesch, e.b.roesch(a)reading.ac.uk. ––– Dr. Etienne B. Roesch Lecturer (Assistant Professor) in Cognitive Science University of Reading, UK http://doodle.com/MeetWithEtienne Too brief of an email? Here's why! http://emailcharter.org

June 7, 2014

an emerging neural theory of grid and place cell development: and navigation: modules, spiking dynamics, cholinergic inactivation, oscillations, and attention

by Stephen Grossberg

The following articles summarize an emerging neural theory of how grid and place cells develop neurophysiological properties that support navigational behaviors, including properties of modular organization, spiking dynamics, effects of cholinergic inactivation, oscillations, and attention. ******************************************************************************************************************************************************************************** Grossberg, S., and Pilly, P. K. (2014). Coordinated learning of grid cell and place cell spatial and temporal properties: multiple scales, attention, and oscillations. Philosophical Transactions of the Royal Society B., 369, 20120524, http://rstb.royalsocietypublishing.org/content/369/1635/20120524.full.pdf+h… Abstract. A neural model proposes how entorhinal grid cells and hippocampal place cells may develop as spatial categories in a hierarchy of self-organizing maps. The model responds to realistic rat navigational trajectories by learning both grid cells with hexagonal grid firing fields of multiple spatial scales, and place cells with one or more firing fields, that match neurophysiological data about their development in juvenile rats. Both grid and place cells can develop by detecting, learning, and remembering the most frequent and energetic co-occurrences of their inputs. The model’s parsimonious properties include: Similar ring attractor mechanisms process linear and angular path integration inputs that drive map learning; the same self-organizing map mechanisms can learn grid cell and place cell receptive fields; and the learning of the dorsoventral organization of multiple spatial scale modules through medial entorhinal cortex to hippocampus may use mechanisms homologous to those for temporal learning through lateral entorhinal cortex to hippocampus (“neural relativity”). The model clarifies how top-down hippocampus-to-entorhinal attentional mechanisms may stabilize map learning, simulates how hippocampal inactivation may disrupt grid cells, and explains data about theta, beta, and gamma oscillations. The article also compares the three main types of grid cell models in light of recent data. **************************************************************************************************************** Pilly, P.K., and Grossberg, S. (2013). Spiking neurons in a hierarchical self-organizing map model can learn to develop spatial and temporal properties of entorhinal grid cells and hippocampal place cells. PLOS ONE, http://dx.plos.org/10.1371/journal.pone.0060599 Abstract. Medial entorhinal grid cells and hippocampal place cells provide neural correlates of spatial representation in the brain. A place cell typically fires whenever an animal is present in one or more spatial regions, or places, of an environment. A grid cell typically fires in multiple spatial regions that form a regular hexagonal grid structure extending throughout the environment. Different grid and place cells prefer spatially offset regions, with their firing fields increasing in size along the dorsoventral axes of the medial entorhinal cortex and hippocampus. The spacing between neighboring fields for a grid cell also increases along the dorsoventral axis. This article presents a neural model whose spiking neurons operate in a hierarchy of self-organizing maps, each obeying the same laws. This spiking GridPlaceMap model simulates how grid cells and place cells may develop. It responds to realistic rat navigational trajectories by learning grid cells with hexagonal grid firing fields of multiple spatial scales and place cells with one or more firing fields that match neurophysiological data about these cells and their development in juvenile rats. The place cells represent much larger spaces than the grid cells, which enable them to support navigational behaviors. Both self-organizing maps amplify and learn to categorize the most frequent and energetic co-occurrences of their inputs. The current results build upon a previous rate-based model of grid and place cell learning, and thus illustrate a general method for converting rate-based adaptive neural models, without the loss of any of their analog properties, into models whose cells obey spiking dynamics. New properties of the spiking GridPlaceMap model include the appearance of theta band modulation. The spiking model also opens a path for implementation in brain-emulating nanochips comprised of networks of noisy spiking neurons with multiple-level adaptive weights for controlling autonomous adaptive robots capable of spatial navigation. ******************************************************************************************************************************************************************************** Pilly, P.K., and Grossberg, S. (2014) How does the modular organization of entorhinal grid cells develop? Frontiers in Human Neuroscience, doi:10.3389/fnhum.2014.0037, http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00337/full Abstract. The entorhinal-hippocampal system plays a crucial role in spatial cognition and navigation. Since the discovery of grid cells in layer II of medial entorhinal cortex (MEC), several types of models have been proposed to explain their development and operation; namely, continuous attractor network models, oscillatory interference models, and self-organizing map (SOM) models. Recent experiments revealing the in vivo intracellular signatures of grid cells (Domnisoru et al., 2013; Schmidt-Heiber and Hausser, 2013), the primarily inhibitory recurrent connectivity of grid cells (Couey et al., 2013; Pastoll et al., 2013), and the topographic organization of grid cells within anatomically overlapping modules of multiple spatial scales along the dorsoventral axis of MEC (Stensola et al., 2012) provide strong constraints and challenges to existing grid cell models. This article provides a computational explanation for how MEC cells can emerge through learning with grid cell properties in modular structures. Within this SOM model, grid cells with different rates of temporal integration learn modular properties with different spatial scales. Model grid cells learn in response to inputs from multiple scales of directionally-selective stripe cells (Krupic et al., 2012; Mhatre et al., 2012) that perform path integration of the linear velocities that are experienced during navigation. Slower rates of grid cell temporal integration support learned associations with stripe cells of larger scales. The explanatory and predictive capabilities of the three types of grid cell models are comparatively analyzed in light of recent data to illustrate how the SOM model overcomes problems that other types of models have not yet handled. ********************************************************************************************************************************************************** Pilly, P.K., and Grossberg, S. (2013). How reduction of theta rhythm by medial septum inactivation may covary with disruption of entorhinal grid cell responses due to reduced cholinergic transmission. Frontiers in Neural Circuits, doi: 10.3389/fncir.2013.00173, http://www.frontiersin.org/Journal/10.3389/fncir.2013.00173/full?utm_source… Abstract. Oscillations in the coordinated firing of brain neurons have been proposed to play important roles in perception, cognition, attention, learning, navigation, and sensory-motor control. The network theta rhythm has been associated with properties of spatial navigation, as has the firing of entorhinal grid cells and hippocampal place cells. Two recent studies reduced the theta rhythm by inactivating the medial septum (MS) and demonstrated a correlated reduction in the characteristic hexagonal spatial firing patterns of grid cells. These results, along with properties of intrinsic membrane potential oscillations (MPOs) in slice preparations of medial entorhinal cortex (MEC), have been interpreted to support oscillatory interference models of grid cell firing. The current article shows that an alternative self-organizing map (SOM) model of grid cells can explain these data about intrinsic and network oscillations without invoking oscillatory interference. In particular, the adverse effects of MS inactivation on grid cells can be understood in terms of how the concomitant reduction in cholinergic inputs may increase the conductances of leak potassium (K+) and slow and medium after-hyperpolarization (sAHP and mAHP) channels. This alternative model can also explain data that are problematic for oscillatory interference models, including how knockout of the HCN1 gene in mice, which flattens the dorsoventral gradient in MPO frequency and resonance frequency, does not affect the development of the grid cell dorsoventral gradient of spatial scales, and how hexagonal grid firing fields in bats can occur even in the absence of theta band modulation. These results demonstrate how models of grid cell self-organization can provide new insights into the relationship between brain learning and oscillatory dynamics. ********************************************************************************************************************************************************************************* Stephen Grossberg Wang Professor of Cognitive and Neural Systems Professor of Mathematics, Psychology, and Biomedical Engineering Director, Center for Adaptive Systems http://cns.bu.edu/~steve steve(a)bu.edu

June 6, 2014

ECML Workshop - “Neural Connectomics: From Imaging to Connectivity”

by Demian Battaglia

ECML Workshop - “Neural Connectomics: From Imaging to Connectivity” September 15, 2014 - Nancy, France Paper submission deadline: June 20, 2014 Description: Systematic extraction of connectivity information is gaining growing importance for the understanding of the general functioning of the brain and its learning capabilities, as well as for designing biomarkers for diagnosis, prediction and prevention in neuropathologies. At the neural level, recovering the exact wiring of the brain (connectome) including nearly 100 billion neurons, having on average 7000 synaptic connections to other neurons, is a daunting task. The goal of this workshop is to bring together researchers in machine learning and neuroscience to discuss progress and remaining challenges in this exciting and rapidly evolving field. We aim to attract machine learning and computer vision specialists interested in learning about a new problem, as well as computational neuroscientists who may be interested in modeling connectivity data. We will discuss also the results of the First ChaLearn Neural Connectomics Challenge, who attracted over 100 participants, many of them advancing considerably the state-of-the-art. Topics of interest to the workshop include, but are not limited to: • building connectomes from EM data • building connectomes from fMRI data • building connectomes from neurophysiology data • bridging neuroanatomy and neurophysiology • connectomics and learning • neuroimaging technology advances • network reconstruction algorithms • causality in time series • feature selection vs. causal discovery • generative vs. discriminative modeling • sharing data • sharing code • organizing new challenges • establishing ground truth, benchmarking • quantitative metrics of evaluation • theoretical understanding Important dates: o Paper submission: June 20, 2014 o Notification of acceptance: July 05, 2014 o Camera-ready: July 25, 2014 o ECML Workshop: September 15, 2014 Important - Submission Guidelines: We encourage contributions in any of these areas. We welcome 2-page short-form submissions and 6-page long-form submissions. Submissions should be formatted using JMLR Workshop and Proceedings format, style files for which are available at: http://www.tex.ac.uk/tex-archive/help/Catalogue/entries/jmlr.html. We also encourage submissions of previously-published material that is closely related to the workshop topic (for presentation only). Everybody can attend the workshop even if he does not participate in the challenge (http://connectomics.chalearn.org/) Challenge participants are encouraged to contribute a paper on their results and also submit papers for presentation on the topics of the workshop. The papers have to be submitted via Easy Chair: https://www.easychair.org/conferences/?conf=ncw2014

June 6, 2014