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Summer internship. Role of the thalamus in sleep oscillatory dynamics underlying memory consolidation
by Carmen Varela April 16, 2019

April 16, 2019

*Paid Summer Research Internship in Systems Neuroscience* *(MIT, FAU)* We are looking for a talented student that will apply analytical techniques to investigate the role of the thalamus in the oscillatory dynamics that organize the consolidation of episodic memory during sleep. The project will involve the analysis of neural data (single cells, local field potentials) from extracellular recordings in sleeping rats. *Requirements:* Outstanding interpersonal and communication skills, demonstrated initiative and dedication, ability to learn fast. Strong analytical skills, including signal processing and programming. EECS, Physics, Computational Neuroscience students encouraged to apply. *What you get: * · Two months of research in systems neuroscience, including the application of analytical techniques to extracellular electrophysiology data. · Spend this summer in the Jupiter campus of Florida Atlantic University, an expanding and interactive neuroscience hub that also holds our partners the Max Planck Florida Institute for Neuroscience and Scripps Research Institute. · Possibility of visiting MIT in August to present results from your work. *Contact:* Submit resume and a brief paragraph commenting on how your skills and background could be helpful to this neuroscience project. Let Dr. Carmen Varela know when you would be available for an interview. varelac(a)fau.edu https://www.thethalamus.org/

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Athens International MSc in Neurosciences -- now accepting 2019-20 applications
by Vassilis Cutsuridis April 16, 2019

April 16, 2019

Apologies for cross-posting – please forward to any interested party. / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / *Applications for the 2019-20 MSc programme in* *Athens International Master's in Neurosciences <http://mastermeuroscience.biol.uoa.gr>* *at National and Kapodistian University of Athens, Greece* *are now OPEN.* / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / This cutting-edge Masters programme is a combined effort of several Athens-based departments and research centers including the - Department of Biology of the National and Kapodistrian University of Athens - Department of Nursing of the National and Kapodistrian University of Athens - Department of Dentistry of the National and Kapodistrian University of Athens - School of Medicine of the National and Kapodistrian University of Athens - Foundation for Biomedical Research of the Academy of Athens - National Center for Scientific Research "Demokritos" - Hellenic Pasteur Institute - Biomedical Sciences Research Center “Alexander Fleming” which builds on the multi-disciplinary research profiles of its staff. Teaching and research staff includes Greek and International professors and researchers of Greek and International Universities and Research Centers. *All lectures are taught in English*. The programme equips students with a rigorous grounding in experimental and computational methods of neurosciences; it also provides them with the opportunity to apply the knowledge they acquired in a practical research project, which may be carried out in collaboration with one of the Masters programme’s industry partners. ** COURSE OUTLINE ** ————————— This is a two-year MSc degree programme, consisting of taught modules (12 months) plus research project and dissertation (12 months). It is designed for students with a good degree in the biological / life sciences (psychology, neuroscience, biology, medicine, etc.) or physical sciences (computer science, mathematics, physics, engineering) interested in how the brain and mind works. The core contents of this programme include (i) fundamentals of experimental neurosciences (developmental neuroscience, cellular and molecular neuroscience, neuroanatomy, neurobiological bases of diseases of the nervous system, neuropharmacology, neuroimmunology, neuroendocrinology. behavioral neuroscience, electrophysiology, neuroimaging), (ii) Lab rotations, and (iii) concepts,methods of computational modelling, data analytics and machine learning. Unlike other standard neuroscience programmes (focusing predominantly either on “low-level” or "high-level" aspects of neuroscience), one of the distinctive features of this programme is that it covers the whole spectrum of the neurosciences bridging the gap between molecular and cellular neuroscience to high-level cognitive processes (e.g., language, attention, and decision making) including computational neuroscience and big data analytics. The final research project and dissertation is carried out in collaboration with an external partner, either from academia or industry. ** WHY STUDY IN ATHENS ** -------------------------------------- Aside from mastering neuroscience, you can also enjoy the largest open-air museum during its mostly sunny and dry days. These include Acropolis and Parthenon, the Odeon of Herodes Atticus, the Arch of Hadrian, the Theatre of Dionysus, Panathenaic Stadium-Kallimarmaro, the iconic Temple of Olympian Zeus, pedestrian avenue of Dionysios Areopagitou, Pnyx Hill, Thiseio, Monastiraki, Plaka and etc, that are full of temples and ancient and Byzantine monuments. In addition, Athens has great museums incunding the Acropolis meuseum, the National Archaeological museum, the museum of Modern Art, the museum of Greek Folk Art and of Greek Folk Musical Instruments, the War Museum, the Benaki Museum, the Museum of Cycladic Art, the National Gallery, and others. You will also have the opportunity to enjoy excellent nature and coast line and the easily reached Aegean islands. ** TUITION FEES ** ————————— *F**ull time EU students*: 2000 Euros per year *Full time non-EU students*: 3000 Euros per year *Part time students*: 500 Euros per semester during the first two years and 1000 Euros per semester during the third year. ** HOW TO APPLY ** ————————— *Applications for the 2019-20 and 2020-21 Academic Years are now open. * To fill in an application, click on this link and follow the instructions: http://masterneuroscience.biol.uoa.gr/admissions.html <https://bit.ly/2Fi86SB> *NOTE: places are limited.* We recommend submitting an application as soon as possible to ensure a place on the programme. For any further information about the programme, please visit: *http://mastermeuroscience.biol.uoa.gr* <https://www.gold.ac.uk/pg/msc-computational-cognitive-neuroscience/> Should you have any questions, please do not hesitate to contact me. I look forward to receiving your application soon! With very best wishes, Professor Spiros Efthimiopoulos ( <M.Garagnani(a)gold.ac.uk>efthis(a)biol.uoa.gr ) — Spiros Efthimiopoulos Professor Director of the Master's Programm: "Athens International Master's Programme in Neurosciences" University of Athens Department of Biology Division of Animal and Human Physiology Central Building, 3nd Floor, Room 38 or 44 157 84 Panepistimiopolis, Ilisia Athens, Greece Tel# ++ 30 210 7274890, ++306974874328 Fax# ++ 30 210 7274635 E-mail: efthis(a)biol.uoa.gr / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /

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Job opening: Visiting Professorship in Machine Learning at Jacobs University
by Herbert Jaeger April 16, 2019

April 16, 2019

Jacobs University Bremen (www.jacobs-university.de) invites applications for a *** 3-year Visiting Professorship in Machine Learning *** The full job description can be found at https://www.jacobs-university.de/visiting-professor-computer-science-mfd-ma… Jacobs University is a small, select, private, research-oriented, English-speaking university with a beautiful campus located at the outskirts of Bremen, a charming old trading seaport in the north of Germany. In the Times Higher Education (THE) worldwide university ranking 2018, Jacobs University ranked in the top 300 in the general ranking, in the 151-175 bracket in Engineering and Technology and in the 176-200 bracket in the Life Sciences. The review of applications will begin immediately and will continue until the position is filled. Ideally, a successful candidate can start on this position in August 2019. - Herbert Jaeger ------------------------------------------------------------------ Dr. Herbert Jaeger Professor for Computational Science Jacobs University Bremen gGmbH Campus Ring 28759 Bremen, Germany Phone (+49) 421 200 3215 email h.jaeger(a)jacobs-university.de http://minds.jacobs-university.de ------------------------------------------------------------------

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[meetings] CfP: Workshop on Naturalistic Non-Verbal and Affective Human-Robot Interactions, IEEE ICDL-EpiRob 2019
by Nicolás Navarro-Guerrero April 15, 2019

April 15, 2019

Apologies for cross-posting. Dear Colleagues, We would like to cordially invite you to submit a paper to the ICDL-EpiRob 2019 workshop on Naturalistic Non-Verbal and Affective Human-Robot Interactions. Call for Contributions and Participation IEEE ICDL-EpiRob workshop on Naturalistic Non-Verbal and Affective Human-Robot Interactions 19th August 2019, Oslo, Norway Website: https://nicolas-navarro-guerrero.gitlab.io/workshop-non-verbal-human-robot-… Humans continually manifest non-verbal and affective cues and expressions used to foster cooperation, mutual understanding and signal trustworthiness. If these cues are not appropriately reciprocated, however, the interaction can be negatively impacted. Moreover, inappropriate reciprocation, or lack thereof, may be the result of misperception and or non-timely reactions. Failure to adequately account for biologically plausible perceptual and temporal facets of interactions may detract from the quality of human-robot interaction and hinder progress in the field of social robotics more generally. Incorporation of naturalistic and adaptive forms of sensorimotor and affective human-robot non-verbal communication is challenging because such interaction is highly dependent on the context and the relationship between the observer and the expresser. Biological species based interaction often requires explicit forms of social signalling such as nodding, nonverbal gestures, emotional expressions, etc., the interpretation of all of which may be highly context-sensitive. Furthermore, naturalistic social signalling may involve a certain degree of mimicry of autonomic responses such as pupil dilation, blinking, blushing, etc. which, in human-robot interaction requires the implementation of time-sensitive perceptual mechanisms currently underused in both commercial and research robotics platforms. In this workshop, we will investigate and discuss to what extent the aforementioned naturalistic social signalling capabilities needs to be accounted for in human-robot interaction and what modalities are more relevant, and in what contexts. The workshop will focus strongly on research motivated by naturalistic empirical data. We hope to provide a discussion friendly environment to connect with research covering complementary interests in the areas of robotics, computer science, psychology, neuroscience, affective computing and animal learning research. The primary list of topics covers the following (but not limited to): * Emotion recognition * Gesture recognition * Social gaze recognition * The development of expression and recognition capabilities * Joint visual attention and activity * Alignment in social interactions * Non-verbal cues in human-robot interaction Invited Speakers Christian Balkenius, Lund University, Sweden Vicky Charisi, Joint Research Centre, European Commission Kerstin Dautenhahn, University of Waterloo, Canada Frank Foerster, University of Hertfordshire, UK Stefanie Höhl, University of Vienna, Austria Yukie Nagai, University of Tokyo, Japan Alessandra Sciutti, Istituto Italiano di Tecnologia, Italy Important Dates Paper submission deadline: 12th May 2019 Notification of acceptance: 7th June 2019 Camera-ready version: 1st August 2019 Workshop: 19th August 2019 Participants are invited to submit short papers (max. 4 pages) following the standard IEEE conference template, link at the workshop webpage. Send your PDF manuscript indicating [ICDL-EPIROB 2019] in the subject to: nng(a)ieee.org . Selected contributions will be presented during the workshop. Organizers Nicolás Navarro-Guerrero, Aarhus University, Aarhus, Denmark Robert Lowe, University of Gothenburg, Sweden Best regards, Nicolás -- Nicolás Navarro-Guerrero Assistant Professor Department of Engineering, and School of Culture and Society Aarhus University, Denmark E-mail: nng(a)eng.au.dk https://nicolas-navarro-guerrero.github.io/ https://socialrobotics.au.dk/ Aarhus University Finlandsgade 22, building 5125 8200 Aarhus N Denmark Tel.: +45 8715 0000 eng(a)au.dk www.eng.au.dk/en/

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Fourth International Workshop on Intrinsically-Motivated Open-endedLearning (IMOL2019)
by Jochen Triesch April 15, 2019

April 15, 2019

Dear Colleagues, We are pleased to announce the “Fourth International Workshop on Intrinsically-Motivated Open-endedLearning (IMOL2019)”, which will be held at Frankfurt Institute for Advanced Studies (FIAS) in Frankfurt (Germany) on 1-2-3 July 2019. The organizers of IMOL 2019 will be - Vieri Giuliano Santucci (ISTC – CNR, Rome) - Kathryn Merrick (University of New South Wales, Canberra) - Jochen Triesch (FIAS, Frankfurt) - Gianluca Baldassarre (ISTC – CNR, Rome) Following three previous editions, the highly focused “Fourth International Workshop on Intrinsically-Motivated Open-ended Learning (IMOL2019)” aims to further explore the promise of intrinsically motivated open-ended lifelong learning. The workshop aims to be a highly interactive event with high-profile keynote presentations (see list of confirmed invited speakers at the end of this message). It will foster close interaction among the participants by discussions, poster sessions, and collective round tables directed toward specific objectives. Participation in the workshop is free of charge but limited to a restricted number of participants. Prospective attendees should express their interest by submitting a brief statement on their motivations to participate, their research interests, and their willingness (or not) to contribute with a poster. The submission should be made by following the instructions at http://www.imol-conf.org/ before the deadline of May, 17th. Both senior and early career researchers, including PhD students, are encouraged to submit to ensure a full representation of the community. Topics of interest involve open-ended lifelong learning in autonomous agents and robots, for example: - Autonomous robots lifelong learning - Multi-task reinforcement learning - Deep reinforcement learning - Intrinsic motivations - Curriculum learning - Goal self-generation - Multiple task solution and parameterized skills - Neural/probabilistic representations and abstractions - Architectures for open-ended learning - Goal-based skill learning - Knowledge transfer and avoidance of catastrophic forgetting - Compositionality and chunking - Hierarchies of goals and skills - Mitigating risks of real-world deployment of open-ended learning systems List of confirmed invited speakers - Luc Berthouze - Marc Bellemare - Bruno Castro da Silva - Stephane Doncieux - Kenji Doya - Richard Duro - Verena Hafner - Matej Hoffman - Petar Kormushev - Georg Martius - Yukie Nagai - Nicolás Navarro-Guerrero - Kevin O'Regan - Matthias Rolf - Elmar Rueckert - Bertram E. Shi - Olivier Sigaud - Jochen Steil - Freek Stulp - Céline Teulière - Emre Ugur (more TBC) -- Prof. Dr. Jochen Triesch Johanna Quandt Research Professor Frankfurt Institute for Advanced Studies http://fias.uni-frankfurt.de/~triesch/ Tel: +49 (0)69 798-47531 Fax: +49 (0)69 798-47611

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CFP: The 2nd International Workshop on Machine Learning in Clinical Neuroimaging (MLCN 2019): ENTERING THE ERA OF BIG DATA VIA TRANSFER LEARNING AND DATA HARMONIZATION
by MLCN Workshop April 15, 2019

April 15, 2019

Dear Colleagues, We are delighted to invite you to join us for the MLCN 2019 <https://mlcnws.com/> workshop as a satellite event of the MICCAI 2019 conference, Shenzhen, China. Call for Papers Recent advances in neuroimaging and machine learning provide an exceptional opportunity for investigators and physicians to discover complex relationships between brain, behaviors, and mental and neurological disorders. The MLCN 2019 workshop (https://mlcnws.com) as a satellite event of MICCAI 2019 (https://www.miccai2019.org) aims to bring together researchers in both theory and application from various fields in domains such as *e.g.* machine learning, neuroimaging, predictive clinical neuroscience, *etc.* Topics of interests include, but are not limited to: - Transfer learning in clinical neuroimaging - Model stability in transfer learning - Data prerequisites for successful transfer learning - Domain adaptation in neuroimaging - Data harmonization across sites - Data pooling – practical issues - Cross-domain learning in neuroimaging - Interpretability for transfer learning - Unsupervised methods for domain adaptation - Multi-site data analysis, from preprocessing to modeling - Big data in clinical neuroimaging - Scalable machine learning methods - Benefits, problems, and solutions of working with very large datasets SUBMISSION PROCESS: The workshop seeks high quality, original, and unpublished work on algorithms, theory, and applications of machine learning in clinical neuroimaging related to big data, transfer learning, and data harmonization. Papers should be submitted electronically in Springer Lecture Notes in Computer Science (LCNS) style ( https://www.springer.com/gp/computer-science/lncs/conference-proceedings-gu…) with up to 8-pages and using the CMT system at https://cmt3.research.microsoft.com/MLCN2019. The MLCN workshop uses a double-blind review process in the evaluation phase, thus authors must ensure anonymous submissions. Accepted papers will be published in a joint proceeding with the MICCAI 2019 conference. IMPORTANT DATES: - Paper submission deadline: July 1, 2019 (23:59 PST) - Notification of Acceptance: August 5, 2019 - Camera-ready Submission: August 12, 2019 - Workshop Date: October 13, 2019 Best regards, MLCN 2019 Organizing Committee <https://mlcnws.com/organization/>, Email: mlcnworkshop(a)gmail.com Website: https://mlcnws.com/ <https://mlcn2018.com/> twitter: @MLCNworkshop <https://twitter.com/MLCNworkshop>

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post-doctoral positions: Neuroscience and Philosophy of Free Will
by Schurger Lab April 13, 2019

April 13, 2019

The post-doctoral positions will be part of a large international project on the neuroscience and philosophy of free will, where some 20 neuroscientists and philosophers will collaborate to explore the neural basis of volition, using experimental, theoretical and computational approaches. Please see here for details: https://braininstitute.us/static-media/uploads/freewill_postdoc_2019.pdf

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Computational Neuroscience Modeler for Neurodegeneration Quantitative Systems Pharmacology Project at Certara
by Hugo-Geerts＠In-Silico-Biosciences.com April 13, 2019

April 13, 2019

Closing Date for Applications: Midnight (UK time), May 12, 2019 Line of Management: Senior Vice President QSP Position Type: Full Time Salary and benefits: Dependent on qualifications, experience and location Location: QSP offices in Sheffield or Canterbury (United Kingdom). Alternative locations and flexible working arrangements can be considered depending on individual circumstances. Job Overview: Certara is expanding its Quantitative Systems Pharmacology (QSP) services in Neurodegeneration and has bold ambitions to revolutionise drug discovery and development in this area of highest medical and societal need. As a result, we have an immediate opening for a Computational Neuroscience Modeller to join our QSP group. This is a unique opportunity to work in a multi-disciplinary team in a world-class organisation and utilise your advanced computational skills to make a difference to the lives of patients with neurodegenerative diseases. Successful applicants will contribute to the development of multi-scale QSP models for neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Specifically, they will develop biophysically realistic neuronal circuit-level computer models, linking pathways, pharmacological effect and clinical outcomes. Requirements: Essential * PhD and at least 2 years postdoctoral experience in computational biosciences * Strong publication record (commensurate with level of experience) * Experience in computational neuroscience and neural modelling with NEURON or equivalent software * Excellent programming skills * Good written and oral communication skills * Combines scientific excellence with ability to make impact in drug discovery and development programs in a timely manner * Ability to work virtually with project teams across different locations and time zones Desirable * Experience in QSP modelling * Experience in modelling neurodegenerative diseases * Experience working in drug discovery and development Company Overview: Certara is a world leader in bio-simulation which combines sophisticated research and development informatics with the power of predictive science methodologies to span the drug development spectrum and offer pharma a previously unavailable 'end-to-end' solution in the quest for improving human health. The Certara UK division develops industry-standard mechanistic models and tools in the areas of physiologically-based pharmacokinetics (PBPK), quantitative systems pharmacology (QSP) and quantitative systems toxicology and safety (QSTS). Certara combines sophisticated research and development informatics with the power of predictive science methodologies to span the drug development spectrum and offer pharma a previously unavailable 'end-to-end' solution in the quest for improving human health. Applications: Please send your CV, covering letter and the names of two references to the Certara Careers Page: www.certara.com

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Postdoc position in the Dutch Research Consortium 'Language in Interaction' (1.0 FTE)
by Verhoef, J.P. (Julia) April 12, 2019

April 12, 2019

Postdoc position in the Dutch Research Consortium 'Language in Interaction' (1.0 FTE) Donders Institute, Centre for Cognitive Neuroimaging Maximum salary: € 4,978 gross/month Vacancy number: 30.05.19 Application deadline: 5 May 2019 [Logo NWO] [Logo Language in Interaction] Responsibilities We are currently recruiting for a 3-year postdoctoral researcher position regarding "Understanding the nature of the mental lexicon" in the Language in Interaction consortium. The goal of this project is to use advanced computational models applied to neural data to understand the structure and function of the language system and obtain a better understanding of the mental lexicon. You will be member of Big Question 1 (BQ1), a larger endeavour to develop computational models of the mental lexicon from linguistic, psychological and neuroscience perspectives. Your responsibility is to develop computational models and apply them to neural data to obtain new neurolinguistic insights. To this end, you will make use of existing publicly available datasets. You will also facilitate collaborative projects in BQ1 that combine the scientific expertise across different work packages. You are expected to take a leading role in translating modeling work to scientific output that provides new insights into the neural correlates of language, as disseminated via high-impact publications. The position also includes a small number of organizational and administrative tasks within BQ1 and the larger consortium. This position provides an opportunity to conduct world-class research as a key member of an interdisciplinary team operating at the interface between artificial intelligence and cognitive neuroscience. Work environment The Netherlands has an outstanding track record in the language sciences. The Language in Interaction research consortium, which is sponsored by a large grant from the Netherlands Organization for Scientific research (NWO), brings together many of the excellent research groups in the Netherlands in a research programme on the foundations of language. In addition to excellence in the domain of language and related relevant fields of cognition, our consortium provides state-of-the-art research facilities and a research team with ample experience in the complex research methods that will be invoked to address the scientific questions at the highest level of methodological sophistication. These include methods from genetics, neuroimaging, computational modeling, and patient-related research. This consortium realises both quality and critical mass for studying human language at a scale not easily found anywhere else. We have identified five Big Questions (BQs) that are central to our understanding of the human language faculty. These questions are interrelated at multiple levels. Teams of researchers will collaborate to collectively address these key questions of our field. Our five Big Questions are: BQ1: The nature of the mental lexicon - How to bridge neurobiology and psycholinguistic theory by computational modeling? BQ2: What are the characteristics and consequences of internal brain organization for language? BQ3: Creating a shared cognitive space - How is language grounded in and shaped by communicative settings of interacting people? BQ4: Variability in language processing and in language learning - Why does the ability to learn language change with age? How can we characterise and map individual language skills in relation to the population distribution? BQ5: How are other cognitive systems shaped by the presence of a language system in humans? You will be appointed at the Donders Institute, Centre for Cognition, Radboud University, Nijmegen, the Netherlands. The project is embedded in the Donders Institute’s research theme "Brain Networks and Neuronal Communication" and will be supervised by Prof. Marcel van Gerven. The research is conducted in an international setting at all participating institutions. English is the lingua franca. What we expect from you We are looking for a highly motivated candidate with a PhD degree in Cognitive Neuroscience, Computational Linguistics, Artificial Intelligence or a related field of research. We expect you to have expertise in the domain of language research, excellent computational skills and Python programming experience, as well as experience with neural data analysis. You will further develop the modeling approaches that are being created within the team and apply these approaches to rich neural datasets to generate new insights about the nature of the mental lexicon. You should have an outstanding scientific track record, excellent organisational, and communication skills, a strong motivation, and high proficiency in written and spoken English. Applications from excellent candidates with a less than ideal profile will also be considered. What we have to offer * employment: 1.0 FTE; * a maximum gross monthly salary of € 4,978 based on a 38-hour working week (salary scale 11); * in addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus; * term of contract: you will be appointed for an initial period of 12 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 24 months; * UFO job profile: Researcher, Level 3; * the Collective Labour Agreement (CAO) of Dutch Universities is applicable to this position; * Dutch universities and the institute involved have a number of regulations in place that enable employees to create a good work-life balance; * you will be able to make use of our Dual Career Service<http://www.ru.nl/dualcareerservice> where our Dual Career Officer will assist with family related support, such as child care, and help your partner prepare for the local labour market and with finding an occupation. Are you interested in our excellent employment conditions<http://www.ru.nl/english/arbeidsvoorwaarden?kn>? Other Information The institute involved is an equal opportunity employer, committed to building a culturally diverse intellectual community, and as such encourages applications from women and minorities. Would you like to know more? Further information on: Language in Interaction<https://www.languageininteraction.nl/> Further information on: Donders Institute<https://www.ru.nl/donders/> For more information about this vacancy, please contact: Prof. dr. Marcel van Gerven, Principal Investigator Artificial Cognitive Systems, and Telephone: +31 24 365 59 31 E-mail: m.vangerven(a)donders.ru.nl<mailto:m.vangerven@donders.ru.nl> Prof. dr. Peter Hagoort, Programme Director Language in Interaction consortium Telephone: +31 24 361 06 48, +31 24 352 13 01 E-mail: p.hagoort(a)donders.ru.nl<mailto:p.hagoort@donders.ru.nl> Are you interested? You should upload your application (attn. of Prof. dr. M. van Gerven) exclusively using the button 'Apply' below. Your application should include (and be limited to) the following attachment(s): * a cover letter * CV, including a list of publications and the names of at least two persons who can provide references Please apply before 5 May 2019, 23:59 CET. [Apply]<https://www.ru.nl/applyonline?recid=601960&tk=uk>

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PhD in Computational and Mathematical Neuroscience (EPSRC funded, 3.5 yrs, Sept 2019 start)
by James Rankin April 12, 2019

April 12, 2019

*PhD in Computational and Mathematical Biology (EPSRC funded, 3.5 yrs, Sept 2019 start) [re-advertised]* General information & apply (funding is primarily targeted at UK students): http://www.exeter.ac.uk/studying/funding/award/index.php?id=3386 Project description: http://www.exeter.ac.uk/codebox/phdprojects/Tabak-EPSRC-DTP-Project.pdf <http://www.exeter.ac.uk/codebox/phdprojects/Rankin-EPSRC-DTP-Project.pdf> *Closing date 13 May 2019. Interviews will be held at the University of Exeter Streatham Campus during the week of 10 June 2019.* Neurons and endocrine cells generate pulses of electrical activity. The patterns of electrical activity vary from cell-to-cell, and characteristics of these patterns (pulse duration, amplitude, timing) are critical to the function performed by the cell. For instance, electric pulse duration and frequency determines the quantity of hormone released by endocrine cells. Electrical currents are produced by ion channels, which act as non-linear electric conductances. The interactions between these non-linear conductances generate the complex patterns of electrical activity. Thus, the exact activity pattern of a given cell depends in a complex way on the exact distribution, or combination of weightings, of the different ion channels. To understand how different combinations of ion channel weightings result in a given pattern of electrical activity, we use mathematical models based on nonlinear differential equations that describe how the conductances vary with the cell electric potential and how they in turn change this potential. The problem with these models is that a lot of parameters are unknown, including the weightings of each channel. Electrophysiologists can record the electrical activity patterns from individual cells, but they cannot measure all the channel weightings from one cell. The objective of this funded PhD project is to extract information about the weightings from the measured electrical activity. The successful candidate will generate a database of channel weighting combinations and compute the resulting electrical activity pattern associated with each combination. They will then apply machine learning and/or topological data analysis to this database. This will allow them to deduce the relationships between weightings across models that generate electrical activity patterns selected from a subset of the database. By identifying the relationships between channel weightings across a highly heterogeneous population we can pinpoint the rules that regulate electrical activity across heterogeneous populations of cells. These methods will then be applied to existing datasets of electrophysiological recordings from electrically active cells. This project provides a unique opportunity to develop experience in machine learning and to receive training in mathematical modelling of neurons. This work will be done in close collaboration with experimentalists using cutting-edge methods that incorporate modelling and electrical recordings together. The student will therefore be exposed to multidisciplinary teamwork. If they so desire, they will also have the opportunity to learn electrophysiology and generate their own dataset of experimental electrical recordings. Candidates with quantitative backgrounds (mathematics, physics, engineering, computer science) are encouraged to apply to this 3.5 year PhD Scholarship. Programming experience, knowledge of dynamical systems theory and experience in biological modelling are a plus. The successful candidate will also be expected to travel to conferences to present their work. *For further information, please contact Dr Joel Tabak J.Tabak(a)exeter.ac.uk <J.Tabak(a)exeter.ac.uk> and Dr James Rankin j.a.rankin(a)exeter.ac.uk <j.a.rankin(a)exeter.ac.uk>* http://emps.exeter.ac.uk/mathematics/staff/jar226

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