January 2024 - Comp-neuro - lists.cnsorg.org

Late-breaking poster abstract submission for the 32nd Annual Computational Neuroscience Meeting ends on June 15
by Rubchinsky, Leonid L 31 May '24

31 May '24

Dear Colleagues, We would like to remind that the late-breaking poster abstracts submission at CNS*2023 ends on June 15. CNS*2023, 32nd Annual Computational Neuroscience Meeting, will be in Leipzig, Germany, on July 15-19, 2023. The information about the meeting and abstract submission can be found here: Registration: https://ocns.memberclicks.net/cns-2023-registration Abstract submission: https://www.cnsorg.org/cns-2023-abstract-submission CNS*2023 information: https://www.cnsorg.org/cns-2023 With kind regards, Leonid Rubchinsky OCNS Vice President *********************** Leonid Rubchinsky, PhD Professor Department of Mathematical Sciences, Indiana University Purdue University Indianapolis Stark Neurosciences Research Institute, Indiana University School of Medicine 402 N. Blackford St Indianapolis, IN 46202-3216 lrubchin(a)iupui.edu http://www.math.iupui.edu/~lrubchin ***********************

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Fully-funded PhD in machine-learning for analysing subject's decisions (Nottingham, UK)
by Mark Humphries 22 Apr '24

22 Apr '24

A fully-funded PhD is available with Dr Silvia Maggi and Professor Mark Humphries (University of Nottingham) and Dr Hazem Toutonji (University of Sheffield). Decision-making happens in dynamic environments. Understanding how subjects respond to such a fast-changing world requires approaches that can track subject's choice strategies at the resolution of single trials. We recently developed a Bayesian inference algorithm (Maggi et al., 2023, bioRxiv) that enables trial-resolution tracking of learning and exploration during learning. This project will build on this work to solve crucial problems of determining which of a set of behavioural strategies a subject is using and how to incorporate evidence uncertainty into its detection of the learning of strategies and transitions between them. Using the extended algorithm on datasets of rodents and humans performing decision tasks will let us test a range of hypotheses for how correct decisions are learnt and what innate strategies are used. Application deadline: November 30th 2023 PhD start date: February 1st 2024 Please send all queries to Silvia (silvia.maggi(a)nottingham.ac.uk) or Mark (mark.humphries(a)nottingham.ac.uk) Full details and how to apply here: https://www.findaphd.com/phds/project/cognitive-flexibility-in-dynamic-deci… Professor Mark Humphries | Professor of Computational Neuroscience Lab: humphries-lab.org<https://www.humphries-lab.org/> Twitter: @markdhumphries Public blog: https://medium.com/the-spike Book: "The Spike: An Epic Journey Through the Brain in 2.1 Seconds" (Princeton UP) out now in paperback: https://press.princeton.edu/books/paperback/9780691241487/the-spike This message and any attachment are intended solely for the addressee and may contain confidential information. If you have received this message in error, please contact the sender and delete the email and attachment. Any views or opinions expressed by the author of this email do not necessarily reflect the views of the University of Nottingham. Email communications with the University of Nottingham may be monitored where permitted by law.

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Postdoctoral Research Fellow in Biocomputation at the University of Hertfordshire, UK
by Volker Steuber 02 Apr '24

02 Apr '24

Post Title: Research Fellow in Biocomputation SBU/Department: School of Physics, Engineering and Computer Science ________________________________ FTE: 1 FTE (working 37 hours per week) Duration of Contract: Fixed term Contract (3 years) Salary: UH7 £36,333 pa with potential to progress to £43,155 pa on achieving designated skills and experience Annual Leave: 35 days plus standard public holidays and an additional 4 days including the closure of our office between Christmas and New Year Location: College Lane Campus, Hatfield, UK Closing Date: 14th June 2023 Interview Date: To be confirmed Reference Number: 048016 Date advert placed: 17th May 2023 Main duties and responsibilities We are seeking a full-time Research Fellow to join the Biocomputation Research Group in the School of Physics, Engineering and Computer Science at the University of Hertfordshire to conduct high-quality research in Computational Neuroscience. The successful candidate’s research will involve synergistic collaborations with a multidisciplinary team to investigate brain processes using methodologies such as computational modelling, machine learning and AI. Research to be conducted could, e.g., comprise modelling brain circuits like the olfactory bulb or the cerebellum and simulating and analysing their function. Additional impact could arise in machine learning, AI, data science, neurorobotics and neuromorphic computing. The successful candidate will be expected to establish a programme of research in collaboration with colleagues at UH and partner organisations in the UK and abroad. Leading the preparation and publication of research manuscripts is a key aspect of the role. Contributions to the preparation of research proposals and applications for funding to external bodies, such as the European Commission and the UK Research and Innovation (UKRI) are expected. The postholder will create opportunities to maximise research activities, capturing relevant evidence to support impact and engaging with external partners and stakeholders. Skill and experience required * Strong theoretical, computational and programming background in computational modelling and/or machine learning and/or data science and/or AI. * Background and expertise in computational neuroscience (e.g. spiking neural networks, brain function and anatomy, analysis of brain data). * Demonstrated experience to conduct independent research in computational neuroscience or a related field, e.g., through published research papers or monographs. * Applicants must be proficient in both written and oral English * The applicants must be able to work independently and in a structured manner and demonstrate good collaborative skills. Qualifications required • An undergraduate honours degree (or equivalent) in Computer Science, Physics, Mathematics, Neuroscience, or a related discipline and a PhD (or expectation that one will soon be awarded) in a relevant discipline. An appointment to this role may require an Academic Technology Approval Scheme (ATAS) certificate. Contact Details/Informal Enquiries: Professor Volker Steuber, v.steuber(a)herts.ac.uk Professor Michael Schmuker, m.schmuker(a)herts.ac.uk Apply through: https://www.jobs.herts.ac.uk/go/048016 Our vision is to transform lives: UH is committed to Equality, Diversity and Inclusion and building a diverse community. We welcome applications from suitably qualified and eligible candidates regardless of their protected characteristics and recognise there are different ways applicants may achieve the criteria in this document. We offer a range of employee benefits including generous annual leave, flexible location opportunities within the UK, discounted Sports Village memberships and free Active Staff sessions, personal and professional development and family-friendly policies. Volker Steuber Professor of Computational Neuroscience Biocomputation Research Group School of Physics, Engineering and Computer Science University of Hertfordshire College Lane, Hatfield, AL10 9AB, UK biocomputation.herts.ac.uk<http://biocomputation.herts.ac.uk>

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Postdoc Position in Moral Artificial Intelligence (Jointly sponsored by Duke and CMU)
by Dr Jana Schaich Borg, Ph.D. 11 Mar '24

11 Mar '24

Postdoc available in our interdisciplinary Moral AI group! Description: We have an opening for a joint two-year postdoctoral position at the School of Computer Science at Carnegie Mellon University and the Social Science Research Institute, Duke Institute for Brain Sciences, and Kenan Institute for Ethics at Duke University (with the possibility of renewal for a third year). The postdoc can be employed through any of these departments in either University, depending on their preference. The candidate is expected to live in either Pittsburgh or Durham depending on their chosen home department, but will be asked to travel occasionally to the other location. The focus of the position is on conducting impactful research on moral artificial intelligence, addressing problems such as: Designing artificial intelligence systems to model and predict human moral judgments Designing effective elicitation mechanisms and interfaces to capture moral preferences Developing techniques for implementing and evaluating AI systems that are based on these modeled preferences, and assessing the dynamic impact of these systems on the preferences and behavior of users who interact with them Qualifications: Applicants should hold a Ph.D. in computer science, statistics, mathematics, computational neuroscience, computational cognitive science, or related technical fields and have expertise in Machine Learning and AI / statistics / data science. Additional background in moral psychology, moral philosophy, (AI or other) ethics, HCI, social decision-making and/or social science is preferred, but not required. Interested applicants should apply online <https://apply.interfolio.com/113237> <https://apply.interfolio.com/113237> (https://apply.interfolio.com/113237) or contact Dr. Jana Schaich Borg via email (js524(a)duke.edu), including a CV and statement of research interests, and the name of three referees that can provide letters of recommendation. We are strongly committed to a diverse academic environment and place high priority on attracting underrepresented candidates.

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Postdoctoral Researcher in Computational Neuroscience: Effects of Neuromodulation on Learning in SRNNs
by Fleur Zeldenrust 05 Feb '24

05 Feb '24

*The 'Biophysics of Neural Computation' group in Nijmegen (PI: dr. Fleur Zeldenrust) is looking for a postdoctoral researcher (26 months) to study the effects of neuromodulators in biologically realistic networks and learning tasks in the Vidi project 'Top-down neuromodulation and bottom-up network computation, a computational study'. You will use cellular and behavioural data gathered by our department over the previous five years on dopamine, acetylcholine and serotonin in mouse barrel cortex, to bridge the gap between single cell, network and behavioural effects.* The aim of this project is to explain the effects of neuromodulation on task performance in biologically realistic spiking recurrent neural networks (SRNNs). You will use biologically realistic learning frameworks, such as force learning, to study how network structure influences task performance. You will use existing open source data to train a SRNN on a pole detection task <https://linkinghub.elsevier.com/retrieve/pii/S0896627315002512> (for rodents using their whiskers) and incorporate realistic network properties of the (barrel) cortex based on our *lab's measurements <https://link.springer.com/article/10.1007/s12021-022-09576-5>*. Next, you will incorporate the cellular effects of dopamine, acetylcholine and serotonin that we have measured (see *this paper <https://doi.org/10.1093/gigascience/giy147>* and *this preprint <https://www.biorxiv.org/content/10.1101/2022.01.12.476007v1>*) into the network, and investigate their effects on task performance. In particular, you will research the effects of biologically realistic network properties (balance between excitation and inhibition and the resulting chaotic activity, non-linear neuronal input-output relations, patterns in connectivity, Dale's law) and incorporate known neuron and network effects. You will build on the single cell data, network models and analysis methods available in our group, and your results will be incorporated into our group's further research to develop and validate efficient coding models of (somatosensory) perception. We are therefore looking for a team player who can collaborate well with the other group members, and is willing to both learn from them and share their knowledge. *Your profile:* Profile - You hold a PhD in computational neuroscience, mathematics, physics, computer science, AI or a similar computational field. - You have experience in working with machine learning models in (computational) neuroscience and are able to perform network simulations, analytical derivations and advanced data analysis. - You are a highly motivated, independent, critical and creative researcher who wants to bridge the gap between real data and abstract theoretical models. - You are a team player, ready to collaborate in a diverse multidisciplinary research group. - You have an excellent command of spoken and written English. - You have experience in coding (Python and/or Matlab). We are *Our profile:* You will be appointed at the *Biophysics of Neural Computation <https://www.ru.nl/donders/research/theme-4-neural-computation-neurotechnolo…>* group, *Donders Centre for Neuroscience <https://www.ru.nl/science/dcn/>*, *Donders Institute for Brain, Cognition and Behaviour <https://www.ru.nl/donders/>*. <https://www.ru.nl/donders/> This vibrant and multidisciplinary institute studies the organisation and function of neural circuits across scales and techniques, from genes and proteins to behaviour and from in vitro and in vivo experiments to computational modelling. It is an open and international environment, where young scientists from different backgrounds share a fascination for the interaction between brain structure and function. Postdoctoral researchers enjoy a *lively community <https://www.ru.nl/donders/talent-education/postdoctoral-researchers/>* and specialised support. *We offer:* We offer - It concerns an employment for 0.8 - 1.0 FTE. - The gross monthly salary amounts to a minimum of €3,226 and a maximum of €5,090 based on a 38-hour working week, depending on previous education and number of years of relevant work experience (*salary scale 10 <https://www.ru.nl/en/staff/services/salary-and-selection-model/salary/amoun…>* ). - You will receive 8% holiday allowance and 8.3% end-of-year bonus. - You will be employed on the basis of a temporary contract for 26 months. - You will be able to use our *Dual Career and Family Care Services <https://www.ru.nl/en/staff/services/living-working-and-studying-netherlands…>*. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment and help your family settle in Nijmegen. - Working for us means getting extra days off. In case of full-time employment, you can choose *between 30 or 41 <https://www.ru.nl/en/staff/services/employment-conditions/working-time/flex…>* <https://www.ru.nl/en/staff/services/employment-conditions/working-time/flex…>days of annual leave instead of the legally allotted 20. *Please, apply via the website before February 11th: * https://www.ru.nl/en/working-at/job-opportunities/postdoctoral-researcher-i… Profil -- Fleur Zeldenrust Associate Professor Donders Institute for Brain, Cognition and Behaviour Donders Centre for Neuroscience Faculty of Science, Radboud University Heyendaalseweg 135, room HG 00.111 6525 AJ Nijmegen, the Netherlands tel +31 24 36 53195 fleurzeldenrust.nl *Due to my own family/work balance, you may receive emails from me outside of normal working hours. I do not expect a response from you outside of your own working pattern, nor do I expect an immediate response when you are working.*

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[Meetings] Extended Deadline - 15 February: 2024 Nengo Summer School
by Michael Furlong 31 Jan '24

31 Jan '24

Dear colleagues, The deadline for application submission to the Nengo Summer School, has been extended to February 15th, 2024. Applications can be submitted at this link:https://forms.gle/xhkNENnpPHeBXu5W7 [All details about this school can be found online at https://www.nengo.ai/summer-school] The Centre for Theoretical Neuroscience at the University of Waterloo is excited to announce our 9th annual Nengo summer school on large-scale brain modelling and neuromorphic computing. This two-week school will teach participants to use the Nengo simulation package to build state-of-the-art cognitive and neural models to run both in simulation and on neuromorphic hardware. Summer school participants will be given on-site access to neuromorphic hardware and will learn to run high-level applications using Nengo! More generally, Nengo provides users with a versatile and powerful environment for designing cognitive and neural systems and has been used to build what is currently the world's largest functional brain model, Spaun, which includes spiking deep learning, reinforcement learning, adaptive motor control, and cognitive control networks. For a look at the last in-person summer school, check out this short video: https://youtu.be/vRcN5-0wdQE We welcome applications from all interested graduate students, postdocs, professors, and industry professionals with a relevant background. ***Application Deadline: February 15, 2024*** Format: A combination of tutorials and project-based work. Participants are encouraged to bring their own ideas for projects, which may focus on testing hypotheses, modelling neural or cognitive data, implementing specific behavioural functions with neurons, expanding past models, or providing a proof-of-concept of various neural mechanisms. Hands-on tutorials, work on individual or group projects, and talks from invited faculty members will make up the bulk of day-to-day activities. A project demonstration event will be held on the last day of the school, with prizes for strong projects! Participants will have the opportunity to learn how to: * interface Nengo with various kinds of neuromorphic hardware (e.g. BrainDrop, SpiNNaker) * build perceptual, motor, and sophisticated cognitive models using spiking neurons * model anatomical, electrophysiological, cognitive, and behavioural data * use a variety of single cell models within a large-scale model  * integrate machine learning methods into biologically oriented models * interface Nengo with cameras and robotic systems * implement modern nonlinear control methods in neural models * and much more… Date and Location: June 2nd to June 14th, 2024 at the University of Waterloo, Ontario, Canada. Applications: Please visit http://www.nengo.ai/summer-school, where you can find more information regarding costs, travel, lodging, along with an application form listing required materials. If you have any questions about the school or the application process, please contact Michael Furlong (michael.furlong(a)uwaterloo.ca). The school is partly supported by ABR, Inc. We look forward to hearing from you!

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Open Postdoctoral Position in the Rich Lab: An Update
by Rich, Scott 31 Jan '24

31 Jan '24

Dear Comp-Neuro Listserv, I am still accepting applications for the open postdoctoral position<https://jobs.hr.uconn.edu/cw/en-us/job/498073/postdoctoral-research-associa…> in my new lab at the University of Connecticut. While applications are being considered on a “rolling” basis, I’m currently planning to perform the first batch of interviews in late February/early March. If you’d like to be considered for a potential interview during this time frame, please apply as soon as possible. As a reminder, I’m also recruiting graduate students. If you’re interested, please express your interest by filling out this Google Form<https://forms.gle/5wtYfXrGuHC2QmLh8> and be sure to apply officially to UConn’s Department of Physiology and Neurobiology (following the instructions here<https://pnb.uconn.edu/graduate/graduate-application-and-admission-informati…>). If you have any questions about these and other opportunities in my lab, please don’t hesitate to contact me. ___________ Sincerely, Scott Rich, Ph.D. Assistant Professor, University of Connecticut Department of Physiology and Neurobiology pnb.uconn.edu/person/scott-rich/ <http://pnb.uconn.edu/person/scott-rich/>scottrich.mystrikingly.com<http://scottrich.mystrikingly.com>

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CFP FRCCS 2024 Montpellier, France May 29 – 31, 2024
by Hocine Cherifi 31 Jan '24

31 Jan '24

Fourth* F*rench* R*egional* C*onference on* C*omplex* S*ystems May 29 – 31, 2024 Montpellier, France *FRCCS 2024* <https://iutdijon.u-bourgogne.fr/ccs-france/> After successfully hosting the conference in Dijon in 2021, Paris in 2022, and Le Havre in 2023, the fourth edition of the French Regional Conference on Complex Systems (FRCCS 2024) will be held in Montpellier, France. This single track international conference organized by CSS France <https://www.cssfrance.org/> serves as a platform to foster interdisciplinary exchanges among researchers from various scientific disciplines and diverse backgrounds, including sociology, economics, history, management, archaeology, geography, linguistics, statistics, mathematics, and computer science. FRCCS 2024 provides a valuable opportunity for participants to meet in France, exchange and promote ideas, facilitating the cross-fertilization of recent research work, industrial advancements, and original applications. Moreover, the conference emphasizes research topics with a high societal impact, showcasing the significance of complexity science in addressing complex societal challenges. Join us in Montpellier as we collectively strive to better understand complexity and its implications for society. You are cordially invited to submit your contribution until *February 21, 2024.* Finalized work (published or unpublished) and work in progress are welcome. Two types of contributions are accepted: · *Papers* about *original research* (up to 12 pages) · *Extended Abstract* about *published or unpublished* research (3 to 4 pages). *Keynote Speakers* · Petter Holme <https://petterhol.me/>, Aalto University, Finland · Sonia Kéfi <https://biodicee.edu.umontpellier.fr/who-we-are/sonia-kefi/>, Université de Montpellier, France · Natasa Przulj <https://www.bsc.es/przulj-natasa>, Barcelona Supercomputing Center, Spain · Boleslaw K. Szymanski <https://www.cs.rpi.edu/~szymansk/> Rensselaer Polytechnic Institute, USA · Ingmar Weber <https://ingmarweber.de/>, Saarland University, Germany *Publication* o Contributions will be included in the conference proceedings (With ISBN) o *Selected submissions of unpublished work will be invited for publication in special issues (fast track procedure) **of the journals:* o Applied Network Science, <https://appliednetsci.springeropen.com/> edited by Springer o Complexity, <https://www.hindawi.com/journals/complexity/?utm_source=google&utm_medium=c…> edited by Hindawi *Submission * · Submit on CMT Microsoft at: https://cmt3.research.microsoft.com/FRCCS2024/ · *Select the Track: FRCCS2024* *Topics include, but are not limited to: * · *Foundations of complex systems * - Self-organization, non-linear dynamics, statistical physics, mathematical modeling and simulation, conceptual frameworks, ways of thinking, methodologies and methods, philosophy of complexity, knowledge systems, Complexity and information, Dynamics and self-organization, structure and dynamics at several scales, self-similarity, fractals - *Complex Networks * - Structure & Dynamics, Multilayer and Multiplex Networks, Adaptive Networks, Temporal Networks, Centrality, Patterns, Cliques, Communities, Epidemics, Rumors, Control, Synchronization, Reputation, Influence, Viral Marketing, Link Prediction, Network Visualization, Network Digging, Network Embedding & Learning. - *Neuroscience, **Linguistics* - Evolution of language, social consensus, artificial intelligence, cognitive processes & education, Narrative complexity - *Economics & Finance* - Game Theory, Stock Markets and Crises, Financial Systems, Risk Management, Globalization, Economics and Markets, Blockchain, Bitcoins, Markets and Employment - *Infrastructure, planning, and environment * - critical infrastructure, urban planning, mobility, transport and energy, smart cities, urban development, urban sciences - *Biological and (bio)medical complexity * - biological networks, systems biology, evolution, natural sciences, medicine and physiology, dynamics of biological coordination, aging - *Social complexity* o social networks, computational social sciences, socio-ecological systems, social groups, processes of change, social evolution, self-organization and democracy, socio-technical systems, collective intelligence, corporate and social structures and dynamics, organizational behavior and management, military and defense systems, social unrest, political networks, interactions between human and natural systems, diffusion/circulation of knowledge, diffusion of innovation - *Socio-Ecological Systems* - Global environmental change, green growth, sustainability & resilience, and culture - *Organisms and populations * - Population biology, collective behavior of animals, ecosystems, ecology, ecological networks, microbiome, speciation, evolution - *Engineering systems and systems of systems* - bioengineering, modified and hybrid biological organisms, multi-agent systems, artificial life, artificial intelligence, robots, communication networks, Internet, traffic systems, distributed control, resilience, artificial resilient systems, complex systems engineering, biologically inspired engineering, synthetic biology - *Complexity in physics and chemistry* - quantum computing, quantum synchronization, quantum chaos, random matrix theory *GENERAL CHAIRS* Roberto Interdonato CIRAD, UMR TETIS, Montpellier Bruno Pinaud LABRI University of Bordeaux Join us at COMPLEX NETWORKS 2024 <https://www.complexnetworks.org/> *-------------------------* Hocine CHERIFI University of Burgundy Franche-Comté Laboratoire* I*nterdisciplinaire *C*arnot de *B*ourgogne - ICB UMR 6303 CNRS Editor in Chief Plos Complex Systems <https://plos.org/complex-systems-research-journal/#:~:text=PLOS%20Complex%2….> Founding & Adisory Editor Applied Network Science <https://appliednetsci.springeropen.com/> Editorial Board member PLOS One <https://journals.plos.org/plosone/>, IEEE ACCESS <https://ieeeaccess.ieee.org/?http%3A%2F%2Fieeeaccess_ieee_org%2F>, Scientific Reports <https://www.nature.com/srep/>, Journal of Imaging <https://www.mdpi.com/journal/jimaging>, Quality and Quantity <https://www.springer.com/journal/11135/>, Computational Social Networks <https://computationalsocialnetworks.springeropen.com/>, Complex Systems <https://www.complex-systems.com/>

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Scientist position at the Allen Institute
by Anton Arkhipov 30 Jan '24

30 Jan '24

Dear Colleagues, A Scientist position is open at the Allen Institute in the area of biologically realistic modeling. Please see the job description here: https://alleninstitute.org/careers/jobs/?jobId=A95FAC9B-4F0F-044B-5458-CAA4… The Scientist will develop bio-realistic network simulations at the level of a cortical area and the whole cortex, leveraging our multimodal datasets on brain composition and connectivity and training models on in vivo data using AI approaches. The goal is to use modeling together with experiments from our collaborators to understand the mechanisms underlying brain responses to sensory stimulation, including periodic sensory stimuli and the resulting entrainment of neuronal populations. Please consider applying and reach out if you have any questions. We are looking forward to hearing from you. Best wishes, Anton Arkhipov Investigator Allen Institute Seattle, WA antona(a)alleninstitute.org<mailto:antona@alleninstitute.org>

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Post-doc or Research Engineer position offer: Computational modeling of genetic mutations at cellular level
by Elif Köksal 30 Jan '24

30 Jan '24

*Context.* Developmental and epileptic encephalopathies (DEEs) are a group of severe rare diseases where the combined effect of seizures, most often drug resistant, and the non-seizures consequences of the disease etiology, often genetic, entail a debilitating encephalopathy with drastic effects on the neurodevelopmental, psychiatric, and motor abilities of the patients. DEEs due to potassium channel mutations (K-DEEs) are emblematic of this disease presentation. *Rationale.* The mechanisms underlying the relationship between i) the molecular effect of a gene mutation (KCNB1/KCNT1/KCNA2) on specific voltage gated potassium channel function, and ii) the patient-specific phenotypes observed in scalp-recorded EEG signals remain elusive. Computational models inspired from neuronal physiology is now recognized as a most efficient way to bridge the gap between i) changes occurringat the level of neurons and neuronal circuits and ii) electroencephalographic (EEG) signals recorded in patients containing markers of the underlying pathology. *Objective.* The objective of the proposed research position is to design novel neuro-inspired models taking into account the molecular effect of a gene mutation on the specific voltage-gated potassium (K) channel function and the specific phenotypes observed in patients (scalp-recorded EEG signals) and in genetically-modified mice (local field potentials) in which downregulation or upregulation of K channels is induced. *Methods*. Detailed multicompartment models (i.e. including dendrites, soma and axon) will be developed. They will be based on Hodgkin and Huxley's (HH) formalism. They will describe both passive (membrane capacitance, axial resistivity, leakage conductance, and membrane time constant) and active (voltage-gated and ligand-gated ion channels) membrane properties. The channel pathogenic variants of KCNB1/KCNT1/KCNA2 mutations identified in 2 other work packages (1 & 2) will be inserted in the membrane in order to study the impact of the channel mutation on the firing rate curves of considered neuron subtypes, typically pyramidal neurons (PYR), somatostatin (SST-), parvalbumin (PV-), and vasoactive intestinal polypeptide (VIP-) positive interneurons. Optimization methods will be developed for identifying optimal parameters minimizing the distance between real and simulated electrophysiological signals (LFPs). Models will use the Hodgkin & Huxley formalism. They will be developed in Python. They will extend already-existing models at cellular level. Strong background is available ( https://perso.univ-rennes1.fr/fabrice.wendling/). *Scientific domains.* Engineering (computational, biomedical); Neuroscience; Neurology; Computer Science (implementation of Python routines into an existing software application named COALIA). *Scientific environment.* This research will benefit from an outstanding clinical research environment, centeredaround the largest curated K-DEE cohorts, coordinated by the Necker reference center for rare epilepsies (Prof. Rima Nabbout), and assembling an extensive group of experts from various specializations, including clinical,electrophysiological, psychological, computational, translational research, biotechnology and pharma industry. *Candidate profile.* The research project is at the interface between biomathematics (neuro-inspired models) and neuroscience/neurology (epilepsy). The Post-doc/Engineer fellow (PhD level) will preferably have a strong background in computational neuroscience/systems biology or in electrical engineering with experience in bio-signal processing. Knowledge in electrophysiology and/or EEG analysis would be an asset. *Contract *The position will be opened March. 1st, 2024 (flexible). The contract is for 3 years (flexible). The employer is the University of Rennes. The competitive salary will be according to experience (2300 Euros net, minimum). The candidate will also have access to the French system benefits. Location in the city of Rennes, France. LTSI-Inserm laboratory, University of Rennes. In addition, the hired person will have the opportunity to actively collaborate with other groups involved in the innov4epik RHU project (2024-2029), funded by the French National Research Agency (ANR). *Contact (please provide resume, cover letter and email of 2 references)* Pascal Benquet (Prof Univ Rennes, LTSI, France) Email: pascal.benquet(a)univ-rennes.fr Fabrice Wendling (DR Inserm, LTSI, France) Email: fabrice.wendling(a)inserm.fr

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