Dear all, Join us at CNS*2023 in Leipzig on July 18th and 19th for the workshop W06: Optimality, evolutionary trade-offs, Pareto theory and degeneracy in neuronal modelling<https://www.treestoolbox.org/CNS2023_pareto_workshop/program.html>. Nervous systems, like any evolved structure, encounter unavoidable trade-offs between multiple tasks. They must fulfil their fundamental computational functions whilst consuming as little energy as possible and remaining robust to potential environmental changes. These tasks are often in direct opposition to one another, and a general quantification of the relative importance of individual optimisation targets is non-trivial. The problem is complicated by the degeneracy seen across neurons and circuits, where multiple different combinations of components can lead to similar functional behaviours. Pareto optimality might provide a useful framework to analyse neurobiological systems from biophysically detailed cells to large-scale network structures that combine high-dimensional parameter spaces with high-dimensional objective spaces. Pareto, or multi-objective, optimality can, for example, help to identify geometrically simple subspaces of neuronal models that cannot be improved upon for all relevant objectives. This workshop aims to discuss applications of Pareto optimality to the trade-offs encountered by diverse nervous systems. The talks and discussions will also address the trade-off between functional effectiveness and energetic efficiency and the concept of metabolically efficient information processing. Registration for the workshops at CNS 2023 is required and can be done at: https://ocns.memberclicks.net/cns-2023-registration Speakers include: Astrid Prinz, Anna Levina, Timothy O'Leary, Marcel Oberländer, Arnd Roth, Rishikesh Narayanan, Suhita Nadkarni, Albert Gidon, Zahid Padamsey, Wiktor Mlynarski, Dylan Festa Full details are available at: https://www.treestoolbox.org/CNS2023_pareto_workshop/index.html and https://cns2023.sched.com/event/1O0MO/w06-optimality-evolutionary-trade-offs... Hope to see you there! Alex Bird, Philipp Norton, Peter Jedlicka, and Susanne Schreiber -- Prof. Dr. Peter Jedlicka Computer-Based Modelling in the field of 3R Animal Protection Faculty of Medicine Justus Liebig University Giessen Rudolf-Buchheim-Straße 6 35392 Gießen Phone: ++49 (0)641 9941387 Fax: ++49 (0) 641 9941359 Email: Peter.Jedlicka@informatik.med.uni-giessen.de 3R Centre of Justus Liebig University Giessen Interdisciplinary Centre for 3Rs in Animal Research (ICAR3R) Frankfurter Straße 104 35392 Giessen (Germany) www.ICAR.de<https://www.uni-giessen.de/de/fbz/fb11/institute/computerbasiertes-modelling/dreir/team>