Dear colleagues, We would like to draw your attention and cordially invite you to submit a manuscript to the Special Issue on Cross-Frequency Coupling in Brain Networks: Methodological Challenges and Functional Implications in BioMed Research International. Manuscripts are due on Friday, 5 December 2014. For more information and to submit a manuscript please see: http://www.hindawi.com/journals/bmri/si/897985/cfp/. We look forward to your contributions. Tjeerd Boonstra Ali Bahramisharif Andreas Daffertshofer Sylvain Baillet Cross-Frequency Coupling in Brain Networks: Methodological Challenges and Functional Implications Synchronous activity of oscillating brain networks plays a fundamental role in cognitive functioning. Cross‐frequency coupling (CFC) has been proposed to be the mechanism for interaction of local and global processes and hence to enable the integration of neural information processing across timescales. We invite investigators to contribute original research articles as well as review articles to stimulate the continuing efforts to understand the neural correlates of CFC, the methodological and mathematical prerequisites for reliable detection of CFC in experimental data, and the functional role of CFC in organizing the temporal dynamics of neural computation.