An outstanding, highly-motivated post-doctoral fellow is sought to participate in studies on the cellular/network mechanisms of optimal state for performance. Candidates experienced in either computational, imaging/optogenetic, or electrophysiological methodologies are sought. We are investigating the mechanisms by which the optimal state for detection and discrimination performance is achieved in mouse neocortex. Mice are trained to perform visual and auditory detection/recognition/discrimination tasks. Through state-of-the-art techniques, such as two-photon monitoring of activity in known neuromodulatory axons in the cortex, whole cell recording of synaptic activity, high density array recordings of cortical unit activity, and optogenetic manipulation of specific transmitter systems, we are able to determine and decipher the role of different transmitter systems and neural pathways that rapidly control neuronal responsiveness. We have recently shown that the waking state varies on a continual basis and that these fluctuations account for a large component of response and behavioral variance. We take a circuit-based approach to systems neuroscience, revealing how the nervous system achieves a goal through the synaptic interaction of cells in local and long range circuits, modulated by neurotransmitters, to generate flexible behavior. Support: Postdoctoral fellows are well supported with state-of-the-art equipment dedicated to their experiments. Salary (45-65K) is competitive and commensurate with experience and contribution. Lab website: www.mccormicklab.org<http://www.mccormicklab.org/> Please contact david.mccormick@yale.edu<mailto:david.mccormick@yale.edu> with inquiries and applications. Send statement of interest, CV, and the names of three people for letters of recommendation. Positions available Fall, 2016. David A. McCormick Professor, Neuroscience | Yale University School of Medicine Dept. Neuroscience 333 Cedar Street | New Haven, CT 06510 | 203.785.5981 www.mccormicklab.org<http://www.mccormicklab.org/> | www.neurobiology.org<http://www.neurobiology.org/>