----------------------------------------------------------------------------- PhD position in the Blue Brain Project - Department of In Silico Neuroscience ----------------------------------------------------------------------------- Project title: Principles of biophysical structural plasticity in the neocortex Supervisors: Prof. Henry Markram, Dr. Eilif Muller Keywords: simulation, neocortex, plasticity, network reorganization, assemblies, coding, dendrites, calcium, NMDA Project description: During our lifetimes, our brains undergo continuous changes as a consequence of our experiences. Synaptic plasticity—the biological process by which brain activity leads to long-term changes in synaptic connections—is thought to be central to learning and memory. However, little is known about how this process shapes the specialization of biological neural networks, such as the neocortex. The objective of the present work will be to devise, implement and study data-driven biophysical models of synaptic and structural plasticity for the formation of functional neocortical networks. This project will leverage the Blue Brain Project data-driven reconstruction of a neocortical microcircuit [1], and augment it with data-driven biophysical calcium-based models of synaptic and structural plasticity. The specific objective of this PhD project will be to implement and constrain models of structural plasticity, and study the formation of assemblies, and emergent structure-function relationships in the presence of structured input. The prospective student will join an ongoing collaboration including international experts in biophysical modeling of plasticity and dendrites, topological analysis of network structure, and optimization of neural simulations for large supercomputers. A significant allocation of computing time on a large HPC system will be at the disposal of this project. [1] Markram, H., Muller, E., Ramaswamy, S., Reimann, M. et al. Reconstruction and Simulation of Neocortical Microcircuitry. Cell 163:2, 456-495 (2015). Key external collaborators: Dr. Michael Graupner (CNRS, Université Paris Descartes), Prof. Idan Segev (Hebrew University Jerusalem) This project is offered in the context of the EPFL Doctoral School in Neuroscience (EDNE). Please visit http://phd.epfl.ch/neuroscience-openings for further details, and information on how to apply. Application Deadline: Nov 15th, 2016. For further details on the project contact: Dr. Eilif Muller <eilif.mueller@epfl.ch> ------------- Dr. Eilif Muller Section Manager - In Silico Neuroscience - Experimentation EPFL - Blue Brain Project Biotech Campus Chemin des Mines 9 1202 Geneva Switzerland Tel: +41 21 693 0698 Fax: +41 21 693 5350 www: http://bluebrain.epfl.ch/page-77926-en.html www: http://neuralensemble.org/people/eilifmuller