Dear Comp-Neuro Community, We would like to bring to your attention that the Research Topic "Advances in Computational Modelling of Neurological Diseases <https://www.frontiersin.org/research-topics/71934/advances-in-computational-...>," hosted in Frontiers in Neurology, is currently open to article submissions. *Scope* This Research Topic seeks to spotlight recent advances in computational modeling of the nervous system under pathological conditions. By integrating mechanistic and data-driven methods, we aim to deepen understanding of neurological disease mechanisms and translate this knowledge into improved diagnostic and therapeutic strategies. The focus is on models that investigate dysfunction across nervous system levels, reveal latent pathophysiological mechanisms from patient data, and simulate the effects of interventions. *Topics (not limited to)* - Biophysical and neuronal network models of neurological disease mechanisms. - Simulation studies of disease progression or intervention outcomes. - Machine learning for the discovery of latent patterns and/or pathophysiological mechanisms in clinical or neuro-behavioral data. - Predictive models for clinical prognosis or treatment response. - Personalised and patient-specific models (e.g., 'digital twins') for capturing individual disease progression and/or targeted therapy. - Integration of computational models with molecular, neuroimaging, electrophysiological, and behavioral data. - Methodological advances and novel computational neuroscience/physiological approaches. *Deadline* February 27, 2026 *Topic Editors* - André Fabio Kohn, University of São Paulo - Francesco Negro, University of Brescia - Leonardo Abdala Elias, University of Campinas - Renan Cipriano Moioli, Federal University of Rio Grande do Norte