Workshop: Detailed models of brain microcircuit activity and signals in clinical applications July 15, 2026, 9:00am-12:30pm ADT At CNS 2026 conference, Halifax, Canada Speakers: Etay Hay Assistant Professor, Centre for Addiction and Mental Health, University of Toronto Heng Kan Yao Postdoc, Centre for Addiction and Mental Health, University of Toronto Salvador Dura-Bernal Associate Professor, State University of New York (SUNY) Downstate Katharina Duecker Postdoc, Brown University Alexandre Guet-McCreight Postdoc, Centre for Addiction and Mental Health, University of Toronto Brain function is mediated by neuronal microcircuits with specific connectivity between neuron types, and it is increasingly evident that altered microcircuitry underlies deficits in brain disorders such as depression and schizophrenia, and in aging and Alzheimer’s. However, our ability to monitor the microcircuitry in living humans is limited, meriting the use of detailed computational simulations to overcome experimental limitations in linking the microcircuit mechanisms with altered cortical activity, functional deficits and biomarkers in clinically-relevant brain signals. This workshop will showcase the latest efforts from leading groups in large-scale neuronal microcircuit modeling of spiking activity and signals such as EEG and MEG. The workshop will present diverse data-driven microcircuit modeling approaches that integrate neuronal, synaptic and functional data, and the different simulation tools used to generate activity and brain signals from the models. The workshop will highlight clinical applications of the models in establishing target mechanisms for treatment, and estimating microcircuit mechanisms from clinical signals in patient data with machine learning to improve diagnosis. This workshop aims to foster the exchange of methods and ideas, and offer new insights on clinical applications of simulated large-scale cortical microcircuits. CONFIDENTIALITY NOTICE: This e-mail message, including any attachments, is for the sole use of the intended recipient(s) and may contain confidential and privileged information. Any unauthorized review, use, disclosure or distribution is prohibited. If you are not the intended recipient, please contact the sender by reply e-mail and destroy all copies of the original message. AVIS DE CONFIDENTIALITÉ : Ce message électronique, ainsi que tout fichier qui y est joint, est reserve à l'usage exclusif du destinataire visé et peut contenir des renseignements confidentiels et privilégiés. Toute lecture, utilisation, divulgation ou distribution non autorisée est interdite. Si vous n'êtes pas le destinataire visé, veuillez en aviser l'expéditeur par retour de courriel et détruire toutes les copies du message original.