We currently have an opening for a postdoc or engineer for the vA-funded neuroprosthetics study described below. If interested, please send a CV to Dr. Dawn Taylor at dxt42@case.edu. The long-term goal of this project is to enable paralyzed individuals to use their brain signals to control their upper limb via implanted muscle stimulators. Most labs working on brain-controlled neuroprosthetics decode intended limb kinematics (e.g. velocity, joint angles, etc.) from the recorded brain signals. However, that approach still requires converting those kinematic commands into the appropriate stimulation patterns required to generate the desired limb motion. That conversion process has not been resolved for the upper limb due to the limb's complex dynamical nature and the fact that the limb is subject to unknown external forces during use. We bypass this obstacle by retraining the brain to control muscle stimulators directly. We have come up with some novel, but clinically feasible ways of mapping neural signals directly to muscle stimulators. Our methods can enable the user to have good control over both limb motion and stiffness. To demonstrate and refine our methods, we are training monkeys to control the movements of a realistic musculoskeletal model of a paralyzed limb activated via implanted muscle stimulators. The paralyzed limb simulator (developed by the lab of Robert Krisch) provides real-time visual feedback to the animal of the limb motion that would result from stimulating the paralyzed muscles based on the animal's neural signals decoded in real time. The use of this real-time paralyzed arm simulator allows us to test and refine our process of brain-controlled muscle stimulation in monkeys without actually having to paralyze any animals. -- Dawn M. Taylor, Ph.D. Assistant Professor of Neuroscience, Cleveland Clinic Researcher Scientist, Cleveland VA Medical Center, Functional Electrical Stimulation Center Assistant Professor of Biomedical Engineering & of Molecular Medicine, Case Western Reserve University The Cleveland Clinic Lerner Research Institute 9500 Euclid Ave. / NC30 Cleveland, OH 44195 email: dxt42@case.edu or taylord8@ccf.org Phone: (216) 636-0140 Fax: (216) 778-4259