Dear all, Due to the request of several researchers needing more time to finalize their manuscript, and also who missed the abstract submission deadline, we are offering a *final* deadline extension to offer a last opportunity of abstract submission and also allow more time for manuscript finalization. Therefore, our Research Topic organized with Frontiers in Neuroscience (Host Specialty: Frontiers in Computional Neuroscience) is still open, and has now an extended deadline for abstract submission and full manuscript submission. As a reminder, our Research Topic is entitled: "Driving Innovation in Therapeutic Brain Stimulation With Biophysical Models" Topic Editors: Julien Modolo, Alexandre Legros and Alex W Thomas - Lawson Health Research and Western University, London, Ontario (Canada). Abstract Submission Deadline: June 30 2014 Full Article Submission Deadline: September 1st, 2014 Research Topic Description: Electric and magnetic stimulation of the brain have become increasingly used for therapy in numerous neurological disorders over the last 20 years. The domain of therapeutic brain stimulation is complex and dynamic, since it involves many different diseases (e.g., Parkinson’s disease, epilepsy), stimulation devices and protocols (from completely non-invasive stimulation to the chronic implantation of stimulation electrodes in the brain). Despite its use by hundreds of thousands of patients worldwide, it seems paradoxical that, in most cases, the biological mechanisms by which therapeutic brain stimulation can provide symptom relief are unknown. Our limited knowledge in terms of interaction mechanisms dramatically slows down the development of novel brain stimulation techniques, which rely mainly on empiric observations. Fortunately, a paradigm change has begun, and biophysical modeling has emerged as an alternative tool not only allowing ot understand therapeutic brain stimulation, but also to foster innovation. Realistic models of neurons and neural networks are now routinely used in neuroscience research to better understand the outcome of experimental data, and also to help in experiment design. These models can simulate the activity of single cells (e.g., with the Hodgkin-Huxley model), or, at the other extreme, of the entire brain (Blue Brain project). One especially appealing use of these models is to simulate in silico how electric and magnetic fields modulate neuronal activity at different spatial and temporal scales, to ultimately have an impact on behaviour. This application of biophysical models of brain activity is currently the focus of intense research efforts, with the hope of groundbreaking clinical translations on the horizon. The objective of this Research Topic is to offer a comprehensive overview of the most recent biophysical models and their contribution in the development of innovative therapeutic brain stimulation techniques, in various neurological disorders. An emphasis should be made on the critical role of biophysical modeling in the rational and effective design of novel brain stimulation techniques, and also in providing key insights into fundamental interaction mechanisms that can be exploited to ends of therapy. About Frontiers Research Topics: Frontiers Research Topics are designed to be an organized, encyclopedic coverage of a particular research area, and a forum for discussion and debate. Contributions can be of different article types (Original Research, Methods, Hypothesis & Theory, and others). Our Research Topic has a dedicated homepage on the Frontiers website, where contributing articles are accumulated and discussions can be easily held. Once all articles are published, the topic will be compiled into an e-book, which can be sent to foundations that fund your research, to journalists and press agencies, and to any number of other organizations. As the ultimate reference source from leading scientists, Frontiers Research Topic articles become highly cited. Frontiers is a Swiss-based, open access publisher. As such an article accepted for publication incurs a publishing fee, which varies depending on the article type. The publishing fee for accepted articles is below average compared to most other open access journals - and lower than subscription-based journals that apply page and color figure charges. Moreover, for Research Topic articles, the publishing fee is discounted quite steeply thanks to the support of the Frontiers Research Foundation. Details on Frontiers’ fees can be found at http://www.frontiersin.org/about/PublishingFees. When published, your article will be freely available to visitors to the Frontiers site, and will be indexed in PubMed and other academic archives. As an author in Frontiers, you will retain the copyright to your own paper and all figures. The details regarding this Research Topic for Frontiers in Computational Neuroscience can be found at the following URL: http://www.frontiersin.org/computational_neuroscience/researchtopics/driving... Should you choose to participate, please confirm by sending a quick email and then your abstract using the following link: http://www.frontiersin.org/submissioninfo Thanks in advance for your interest! Julien Modolo, Alexandre Legros and Alex W Thomas -- Julien Modolo, PhD Scientist, Human Threshold Research Group, Lawson Health Research Institute Assistant Professor, Departments of Medical Biophysics and Medical Imaging, Western University Room E4-141 268 Grosvenor Street London, ON, N6A4V2 Canada Phone: (+001) 519-646-6100 ext 64192 Fax: 519-646-6100