Dear List, My apologies for cross-postings first of all! I would like to draw your attention to our second online seminar on Connectomics. We have invited our clinical neuroimaging specialist Dr Yong Li from Biomax Brain Science to demonstrate how brain tumors change the human Connectome and how the Connectome heals after tumor surgery. Abstract at the end of this message. The seminar takes place online on Tue, 10 Nov 2020 at 3pm (CET). Participation is free of charge but registration is kindly requested via this link https://www.biomax.com/webinar Explore NICARA yourself by registering a free demo account at https://ssl.biomax.de/nicara/ Kind regards, Markus == *Abstract* Brain damage such as tumors, traumatic brain injury or stroke alter the characteristics of the broader connectome—the map of all neural connections in the brain. A hot topic in ongoing research using the connectome approach is how brain rewiring can compensate for lesion-induced cognitive deficits before and after intervention. The site of a lesion within the connectome is critical. Damage of a node that acts e.g. as an integrator hub of several subnetworks is significantly more detrimental to cognitive functions than a damaged node with low connectivity or existing by-passes. Understanding brain rewiring in response to lesions is the major focus of clinical as well as computational neuroscience projects (such as The Virtual Brain) to pave the way for personalized medicine in neurology and related fields. In this online seminar we will focus on brain tumors and explore their effects on the connectome using NICARA™. A particular image processing pipeline in NICARA, employing the best available open-source tools for image preprocessing and probabilistic fiber tracking, enabled us to automatically extract full brain tractography based structural connectome data from DTI raw images. Besides the pipeline, we will discuss quality control mechanisms especially designed for the assessment of large cohorts. As an example, data set we used the Brain Tumor Connectomics Data (Aerts H et al. Modeling Brain Dynamics in Brain Tumor Patients Using the Virtual Brain. eNeuro. 2018 Jun 4;5(3): ENEURO.0083-18.2018.) and assessed alterations in major white matter fiber tracts before and after surgery. For quantification, provided not only the abstract presentation of digitalized connectome networks in MNI space by a 3D lattice graphs but also offered fiber density maps directly in the patient’s native T1w for a precise judgement of fiber pathway density distribution in the vicinity of, and remote to, a tumor. Our clinical neuroimaging specialist Dr. Yong Li will further show how he uses NICARA to explore, manage and compare extracted connectome networks for group comparisons, individual patient-matched controls comparisons and longitudinal assessments. NICARA is a novel neuroimaging tool created by clinical neuroimaging scientists for clinical and translational neuroscience users. A technical introduction by product manager Dr. Markus Butz-Ostendorf at the end of the seminar on how NICARA stores and retrieves connectome information using of knowledge models will complement the scientific presentation. The seminar will take place on November 10, 2020 at 3:00 p.m. (CET) and will last about 45 minutes. Make use of this opportunity and register today at www.biomax.com/webinar. Next seminar for Pharmacologists : 1/12/2020, 3:00 pm       To register, please go to https://www.biomax.com/webinar and request your access data via the webinar page. We are looking forward to meeting you. -- Dr. rer. nat. Markus Butz-Ostendorf Innovation Manager Brain Science Senior Product Manager Biomax Informatics AG Robert-Koch-Str. 2, 82152 Planegg, Germany Registergericht: Amtsgericht München, HRB 134442 Vorstand: Dr. Klaus Heumann Vorsitzender des Aufsichtsrates: Prof. Dr. Hans-Werner Mewes Tel: +49 89 895574-862 Fax: +49 89 895574-825 Email:markus.butz-ostendorf@biomax.com Website:http://www.biomax.com PGP:https://ssl.biomax.de/pgp/