Important: North America moved to daylight savings time on March 10 Please check the time in your country ------------------- [image: VVTNS.png] https://www.wwtns.online - on twitter: wwtns@TheoreticalWide You are cordially invited to the lecture given by Manuel Beiran Columbia University on the topic of "Prediction of neural activity in connectome-constrained recurrent networks *"* The lecture will be held on zoom on *April 3, 2024*, at *11:00 am EDT * To receive the zoom link: https://www.wwtns.online/register-page *Abstract: *In this talk, I will explain a theory of connectome-constrained neural networks in which a “student” network is trained to reproduce the activity of a ground-truth “teacher”, representing a neural system for which a connectome is available. Unlike standard paradigms with unconstrained connectivity, here both networks have the same connectivity but they have different biophysical parameters, reflecting uncertainty in neuronal and synaptic properties. We find that the connectome is often insufficient to constrain the dynamics of networks that perform a specific task, illustrating the difficulty of inferring function from connectivity alone. However, recordings from a small subset of neurons can remove this degeneracy, producing dynamics in the student that agree with the teacher. Our theory can prioritize which neurons to record from to most efficiently unmeasured network activity. The analysis shows that the solution spaces of connectome-constrained and unconstrained models are qualitatively different, and provides a framework to determine when such models yield consistent dynamics. *About VVTNS : Created as the World Wide Neuroscience Seminar (WWTNS) in November 2020 and renamed in homage to Carl van Vreeswijk in Memoriam (April 20, 2022), its aim is to be a platform to exchange ideas among theoreticians. Speakers have the occasion to talk about theoretical aspects of their work which cannot be discussed in a setting where the majority of the audience consists of experimentalists. The seminars, **held on Wednesdays at 11 am ET,** are 45-50 min long followed by a discussion. The talks are recorded with authorization of the speaker and are available to everybody on our YouTube channel.* -- 'Life is good ..' (Carl van Vreeswijk, 1962-2022) --------------------------------------- David Hansel Directeur de Recherche au CNRS Co-Group leader Cerebral Dynamics Plasticity and Learning lab., CNRS 45 rue des Saints Pères 75270 Paris Cedex 06 Tel (Cell): +33 607508403 - Fax (33).1.49.27.90.62 ᐧ