Dear Colleagues, We are happy to announce the release of DynaSim, an open-source MATLAB/GNU Octave toolbox for rapid prototyping of neural models and batch simulation management. It was designed to speed up and simplify the process of generating, sharing, and exploring network models of neurons with one or more compartments; it is the first, comprehensive neural modeling and simulation platform developed in MATLAB. It provides C compilation, optimized vector calculations, multi-core processing, and support for compute clusters to overcome the traditionally slow simulation speeds of MATLAB. It is also available for high performance computing via the Neuroscience Gateway web portal. A paper introducing DynaSim was recently published in Frontiers in Neuroinformatics: https://www.frontiersin.org/articles/10.3389/fninf.2018.00010/full. Documentation is available online at http://dynasimtoolbox.org. We hope this tool reduces barriers for investigating dynamics in neural models, facilitates collaborative modeling, and complements other tools being developed in the neuroinformatics community. Most of all, we hope you find this toolbox useful! Please direct questions to the lead developer, Jason Sherfey < sherfey@mit.edu> or the user mailing list: https://groups.google.com/forum/#!forum/dynasim-users. Best regards, Jason Dr. Jason Sherfey Postdoctoral Research Fellow Psychological & Brain Sciences, Boston University Massachusetts Institute of Technology The Picower Institute for Learning & Memory http://JasonSherfey.com