PhD position in theoretical and experimental neuroscience Application deadline: 30/05/2020 What: PhD position in theoretical and experimental neuroscience Where: Bordeaux, France When: September 2020 (3 years duration) Who: Nicolas Rougier (Inria) & Arthur Leblois (CNRS) A PhD position is available at the Inria Bordeaux Sud-Ouest center and the Institute of Neurodegenerative Disease in Bordeaux, France. Candidate profile ================= The future PhD candidate must have a strong experience at both the theoretical and experimental level. In particular, the following qualities and skills will be highly valued, if not required: * Solid bases in maths and/or physics; * Previous experience in experimental neuroscience; * Programming experience (Python or similar coding language); * Experience in machine learning or data mining is a plus; * Independence and ability to manage a project; * Good English reading/speaking skills. How to apply ============ Please send your application (CV, letter of motivation, and the names and email addresses of one or two persons who can provide recommendation letters) to Dr. Nicolas Rougier (nicolas.rougier@inria.fr) and Arthur Leblois (arthur.leblois@univ-bordeaux.fr) before the 30th of May 2020. Proposed research ================= Temporally precise movement patterns underlie many motor skills and innate actions, yet the origin of temporal control in motor behaviors remains unclear. While cortical motor regions traditionally have been viewed as encoding features of motor gestures, these models do not address how sequences of motor gestures are produced or appropriately timed. Recently, a number of studies have suggested that, beyond just representing features of motor output, motor regions may have intrinsic oscillatory dynamics or sequential dynamics to act as their own pattern generators. However, in the order of milliseconds, the neural and anatomical correlates of time processing are still largely unknown because the dominant model, which is based on internal clock fails at giving account on experimental data. Understanding the neural dynamics underlying the acquisition and performance of complex sensorimotor tasks has been hindered by the complexity of the underlying brain networks in common animal models used in neuroscience (e.g. rodents or primates). In particular, the complex interactions between cortical areas (primary and secondary motor cortex in rodents, motor, premotor and supplementary motor areas in primates) related to many different sensorimotor associations and motor skills is daunting. Conversely, in birds, the sensorimotor skill of song production and its learning has a dedicated set of interconnected brain nuclei known as the “song system”, making them an outstanding model to study the neural mechanisms of vocal learning and more generally, of sensorimotor learning. Songbirds indeed rely on learned vocalizations to communicate during courtship or aggressive behaviours. Just as speech learning in humans, vocal learning in young birds requires the coordination of vocal muscles to reproduce previously experienced adult vocalizations. Song learning is also limited to a critical period during development and heavily relies on auditory feedback. The proposed research lies at the interface of neurophysiology, cognitive science, applied mathematics, and theoretical physics. The concepts and methods that will be used will draw on single neuron physiology, electrophysiological studies in behaving animals, statistical mechanics, dynamical system theory, and stochastic differential equations. To this end, we will combine a theoretical approach (development of a mathematical model of the timing system) and an experimental one (chronic neural recording in awake birds, behavioural manipulations). Therefore, a collaboration with a team of physiologists at the Institute of Neurodegenerative Diseases, and in particular with Arthur Leblois who has a long-established expertise in the neural mechanisms underlying vocal learning in songbirds. The model will be designed under the supervision of Nicolas Rougier who has extensive experience in computational modelling. Predictions of the model will then be tested experimentally by measuring neuronal activity in the brain areas controlling song timing in songbirds under the supervision of Arthur Leblois. Chronic electrophysiological recordings in singing birds are routinely performed in the lab of Arthur Leblois, and will be implemented in a protocol allowing the induction of plasticity in the duration of song syllables in young adult birds over short periods of time.