We are glad to announce the *EBRAINS Brain Simulation School 2022* to be held in Palermo, Italy, from 30 May to 3 June, 2022. The EBRAINS Brain Simulation School 2022 aims at introducing the participants to the latest achievements and innovations of the *digital infrastructure for brain research EBRAINS* (ebrains.eu), created by the Human Brain Project. The School will offer tutorials on EBRAINS Tools and eServices. The students will be presented with the overview of the EBRAINS research platform, discussed by the leaders of the Human Brain Project, and gain practical skills in using EBRAINS resources to implement cellular and network level computational models, to use *EBRAINS Computing Services* configure and run simulations, and to visualise/analyse the results. Through tutorials, interactive sessions and hands-on activities, attendees will learn how to interact with EBRAINS to *carry out their own research*, to set up and manage a data-driven collaborative project, or to use the EBRAINS platform to interact with internal and external databases. The *target audience* of this school are advanced master students, doctoral students and postdoctoral researchers in biomedical and technology sciences, from medicine, biology, psychology, to mathematics, informatics, information technology, physics, chemistry, who would like to get an *introduction to the neuroinformatics and computational neuroscience tools available in the EBRAINS Infrastructure*. Registrations close on *30 April, 2022*. The event is limited to *40 participants*. Registration and Program are available on the School website: https://www.humanbrainproject.eu/en/education/BRAINSIM/ The School Scientific Chairs & Organizers Michele Migliore, Aušra Saudargienė, Francesca Spataro, Alessia Bonafede