Dear Colleagues, We are pleased to announce the CNS*2025 Workshop “Modeling extracellular potentials: principles, methods, and applications” which will take place on Wednesday, July 9, 2025, in Florence, Italy. Simulating large-scale neural activity is a key step in understanding brain dynamics and in linking in silico models to experimentally measurable signals such as LFP, EEG, and MEG. These simulations, ranging from detailed biophysical reconstructions to simplified proxies, enable us to connect microscale neuronal activity with meso- and macro-scale brain signals. They offer powerful tools to interpret experimental data, refine analytical techniques, and investigate brain function. Recent developments have underscored the clinical and theoretical relevance of such models, helping to elucidate mechanisms underlying neural oscillations, excitation-inhibition balance, and biomarkers of neurological disorders including epilepsy, Alzheimer’s disease, and Parkinson’s disease. This workshop will showcase state-of-the-art methodologies, and a wide array of applications for brain signals simulation. By bringing together experts from diverse fields, it aims to foster interdisciplinary exchange and advance our understanding of both healthy and disordered brain function. Abstracts of all talks are available on the workshop website: https://nicolomeneghetti.github.io/ECP_CNS2025_Wshop/ Workshop program: 09:15 – 09:50 | Dominik Peter Koller, Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin, Berlin, Germany Title: "How structural connectivity directs cortical traveling waves and shapes frequency gradients" 09:50 – 10:25 | Gaute T. Einevoll, Department of Physics, University of Oslo, Oslo, Norway Title: "Modeling electric brain signals and stimulation" 10:30 – 11:00 | Coffee Break 11:00 – 11:35 | Johanna Senk, Institute for Advanced Simulation (IAS-6), Jülich Research Centre, Jülich, Germany Title: "Large-scale modeling of mesoscopic networks at single-neuron resolution" 11:35 – 12:10 | Pablo Martínez Cañada, Research Centre for Information and Communications Technologies (CITIC), University of Granada, Granada Title: "Inverse Modelling of Field Potentials from Simulations of Spiking Network Models: Applications in Neuroscience Research and Clinical Settings" 12:10 – 12:40 | Nicolò Meneghetti, The Biorobotics Institute, Sant’Anna School of Advanced Studies, Pisa, Italy Title: "From microcircuits to mesoscopic signals: a kernel approach to efficient and interpretable LFP estimation" 12:45 - 14.00 | Lunch Break 14:15 – 14:50 | Emily Patricia Stephen, Department of Math and Statistics, Boston University, Boston, MA, United States of America Title: "Connecting biophysical models to empirical power spectra using Filtered Point Processes" 14:50 - 15:25 | Madeleine Lowery, School of Electrical and Electronic Engineering, University College Dublin, Dublin, Ireland Title: "Modelling Neural Activity During Adaptive Deep Brain Stimulation for Parkinson’s Disease" 15:30 - 16:00 | Coffee Break 16:00 – 16:35 | Meysam Hashemi, Aix Marseille University INSERM, INS, Institute for Systems Neuroscience, Marseille, France Title: "Principles and Operation of Virtual Brain Twins" 16:35 - 17:10 | Katharina Duecker, Brown University and University of Birmingham, USA/UK Title: "The Human Neocortical Neurosolver as an interactive modeling tool to study the multi-scale mechanisms of human EEG/MEG signals" We look forward to your participation in what is shaping up to be a lively and insightful workshop. With best regards, Nicolò Meneghetti and Eleonora Russo