A PhD position is available to work with Peter Jedlicka (Justus Liebig University Giessen and Goethe-University Frankfurt) in a project aimed at computational modeling of hippocampal neurons. The PhD student will be involved in the generation and implementation of computational models focusing on synaptic plasticity and excitability of hippocampal neurons. The student will be using computer models to reproduce/predict data from electrophysiology experiments and developing simulation tools contributing to 3R animal protection strategies. The successful candidate should have a background in physics, mathematics, engineering, computational neuroscience, computational biology or a related field. Experience in scientific programming is necessary. Experience with compartmental modeling is a plus. The project includes morphological modeling in close collaboration with Dr. Hermann Cuntz (FIAS and Ernst-Strüngmann Institute, Frankfurt). The successful candidate will also collaborate with experimental and computational labs in Giessen and Frankfurt. Please submit your application, CV and statement of research interests to: Prof. Dr. Peter Jedlicka (Peter.Jedlicka@informatik.med.uni-giessen.de) Computer-Based Modeling in the field of 3R Animal Protection, Faculty of Medicine, Justus-Liebig-University, Giessen The project is related to these recent publications: Platschek S, Cuntz H, Vuksic M, Deller T, Jedlicka P. A general homeostatic principle following lesion induced dendritic remodeling. Acta Neuropathol Commun., 4:19 2016 Jedlicka P, Benuskova L, Abraham WC. A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent "Heterosynaptic" LTD in the Dentate Gyrus In Vivo. PLoS Comput Biol. 11(11):e1004588, 2015 Beining M, Jungenitz T, Radic T, Deller T, Cuntz H, Jedlicka P, Schwarzacher SW. Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells. Brain Struct Funct. 222:1427-1446, 2017 -- Prof. Dr. Peter Jedlicka Computer-Based Modelling in the field of 3R Animal Protection Faculty of Medicine Justus-Liebig-University Rudolf-Buchheim-Str. 6 D-35392 Giessen