We would like to invite you to an upcoming COSYNE workshop that is very relevant for the computational neuroscience community! Title: Closed-loop control of neural systems and circuits for scientific discovery Tuesday, March 6, 2018 Organizers: Christopher Rozell, Garrett Stanley With the advent of new technologies for interfacing with neural systems, there are exciting opportunities emerging that enable us to manipulate neural systems and circuits while simultaneously monitoring their activity. These new sensing and actuation strategies hold the promise of more powerful techniques for functionally dissecting complex neural circuits to uncover their operating principles and potentially develop novel clinical therapies. With a common goal of neural control, a variety of researchers ranging from theorists to experimentalists are currently developing techniques for estimating system states from recorded data and making real-time updates to stimulation. This topic is particularly timely because of the confluence of technological advances in recording, stimulation, and algorithms that enable closed-loop stimulation studies in circuits, and for increasing government and private support for research in these and related areas. Such closed-loop techniques will enable an entirely new class of experimental manipulations that promise new insight into circuit function in health as well as disease. Given that the first papers using closed-loop stimulation of neural circuits have only recently appeared in the literature and there is finally a critical mass of people working on these exciting problems, now is the perfect time to bring a community together around this emerging area. The overarching goal of this workshop is to foster a discussion to illuminate a set of community research goals to accelerate the impact of closed-loop stimulation techniques in neuroscience. This workshop will provide a venue for researchers building the components of these closed-loop stimulation systems and researchers using these tools for scientific discovery and clinical treatments. Specifically, the target audience includes neuroscience researchers who are using (or want to be using) closed-loop stimulation of neural circuits in scientific studies or treatment for disorders, computational neuroscientists developing the foundations for analysis and design of algorithms necessary for closed-loop control (include modeling and state estimation), and neuroengineering researchers building elements of experimental systems (interfaces, algorithms and hardware). Morning session 8:00-8:15a Introduction and opening remarks by organizers and representatives from BRAIN Initiative and IEEE Brain 8:15-8:40a Maryam Shanechi, Dynamic modeling of brain network response to stimulation: a computational framework with binary-noise modulated waveforms 8:40-9:05a Memming Park, Myopic control of neural dynamics 9:05-9:35a Coffee break 9:35-10:00a Danielle Bassett, Perturbation and control of human brain networks 10:00-10:25a Hillel Adesnik, Precise control of neural ensemble activity with multiphoton holographic optogenetics 10:25-11:00a Christopher Rozell & Garrett Stanley, Closed-loop optogenetic control in vivo: tracking dynamics and states Afternoon session 4:30-4:55p Jeanne Paz, Optogenetic Closed loop control of thalamocortical seizures in animal models of genetic and acquired epilepsies 4:55-5:20p Sridevi Sarma, Suppressing seizures via closed-loop stimulation of the epileptogenic zone 5:20-5:50p Coffee break 5:50-6:15p ShiNung Ching, Controlling the Meaning of Spikes: Strategies for Extrinsic Manipulation of Neural Information Processing 6:15-6:40p Chethan Pandarinath, LFADS: a deep learning method to infer latent states and dynamics from neural population activity 6:40-7:30 Panel discussion and concluding remarks