Dear friends and colleagues, We are pleased to announce that this Saturday, July 5, in Florence, Italy, we will be hosting a full-day tutorial at CNS*2025 on "Building Intuitive and Efficient Biophysical Models with Jaxley and DendroTweaks". This tutorial will introduce two new software tools, Jaxley and DendroTweaks, which provide complementary approaches for developing detailed biophysical models. The tutorial will feature interactive, hands-on sessions using Jupyter notebooks, where participants will learn how to: - Build neuronal models with realistic dendritic morphology and ion channels - Understand the role of each model parameter through interactive visualizations - Refine data and standardize models - Speed up simulations using a GPU-based simulator - Optimize model parameters automatically using gradient-based approaches - Train networks of biologically realistic neurons to solve complex tasks, bridging the gap between neuroscience and AI This tutorial is open to researchers and students of all levels interested in computational neuroscience. No prior experience with biophysical modeling is required. A basic familiarity with Python is helpful but not necessary. Software tools: Jaxley: https://jaxley.readthedocs.io/ DendroTweaks: https://dendrotweaks.dendrites.gr/ Speakers and organizers: Spyridon Chavlis, Michael Deistler, Kyra L Kadhim, Roman Makarov Schedule: 09:00 – 09:15 Welcome and general introduction 09:15 – 10:10 Building single-neuron models with DendroTweaks 10:10 – 10:40 Coffee break 10:40 – 12:00 Exploring models in DendroTweaks GUI 12:00 – 13:00 Lunch break 13:00 – 14:30 Building single-cell and network models in Jaxley 14:30 – 15:00 Coffee break 15:00 – 16:00 Optimizing biophysical models with Jaxley See more here: https://cns2025florence.sched.com/event/25kVa/building-intuitive-and-efficie... We are looking forward to seeing you in Florence. On behalf of the organizers, Spiros Chavlis