Passing this on for a colleague - contact the email address in the job ad for more information. RESEARCH ENGINEER Axion BioSystems, Inc. is a life science company located in Atlanta, GA. We design, develop and manufacture instrumentation used for the precise monitoring and control of excitable cells. Axion’s products are used by pharmaceutical and biotech companies, governmental agencies, and universities for drug safety, drug discovery, and disease modeling assays. We are currently seeking an energetic scientist to lead Axion’s efforts in a collaboration with the Institute for Genomic Medicine (IGM) at Columbia University. The objective of the collaboration is to interrogate the genetic mechanisms of epilepsy with multiwell microelectode array (MEA) technology. The newly developed IGM is an integral part of Columbia University’s Precision Medicine Initiative. As part of this Initiative, the IGM performs comprehensive genomic analyses on more than 10,000 patient genomes per year in order to identify new therapeutic targets of neurodevelopmental disorders including epilepsy. In order to understand how the implicated mutation affects disease, the laboratories of David Goldstein and Michael Boland use both primary neurons from mouse models of epilepsy and neurons derived from human induced pluripotent stem cells to study the effects of epilepsy gene mutations on neurodevelopment and neural network behavior. The selected individual will contribute analytical and electrophysiological expertise to complement a highly skilled team of molecular biologists. JOB FUNCTIONS: • Execution of neurophysiological experiments with the multiwell MEA platform. The ability to interpret or debug experiments in real-time is important, such as distinguishing signal from noise or artifacts. • Analysis of large electrophysiological data sets, primarily from the multiwell MEA platform, but also including complementary in vivo data. • Develop experimental hypotheses and identify expected results. Must confirm results through independent analysis and investigate any discrepancies that appear, while understanding the strengths and limitations of model systems (i.e., cellular vs. animal). • Drive innovation of the multiwell MEA assay, leading to new experimental methods and analytical techniques. • Work well in a fast-paced, collaborative environment at Columbia University in New York City, with an ability to communicate well with the Axion team in Atlanta. REQUIREMENTS: • PhD in neuroscience or neuroengineering. A recent post-doc experience is a plus. • Hands-on research experience with electrophysiology techniques. Specific experience with MEA technology is desired. • Biostatistical and data analysis experience. • Experience with software analysis tools such as MATLAB or MiniTAB. • Attention to detail with good documentation and communication skills. • U.S Citizenship or permanent residency required. USEFUL KNOWLEDGE: The following are not required, but will enhance an applicant’s candidacy. • Hands on experience in general biological protocols including knowledge of primary cell dissociation, cell culture protocols, CRISPR, gene editing, and basic molecular techniques. • Experience with screening technologies, such as high-throughput patch clamp or high content imaging. • Knowledge of pharmacology and neurotoxicity research. CONTACT INFORMATION: If you are interested in this position, please send your resume and cover letter to careers@axionbio.com