Dear colleagues, We are excited to announce a Research Topic in Frontiers in Neuroscience - section Neuroprosthetics titled "Improving Neuroprosthetics through Novel Techniques for processing Electrophysiological Human Brain Signals". This research topic focuses on innovative approaches for translating current research results into useful clinical applications providing novel therapeutic possibilities in the neurorehabilitation and neuroprosthetic field. The development of these novel solutions could help people with disabilities to overcome their daily obstacles and achieve a better quality of life. We are thus widely open to contributions that target: * novel experimental designs, clinical protocols, and applications involving brain signals in the context of neurorehabilitation; * techniques for off-line signal processing, e.g. investigation of brain activity (EEG, EcoG, stereo-EEG, MEG), characterization of brain oscillations, decoding of information in the brain (e.g. sensory and/or motor); * techniques for on-line signal processing, e.g. novel hardware design for treating human brain signals; * assessment of plastic changes following a neurorehabilitation treatment or upon usage of a prosthetic device, e.g. novel biomarkers based on electrophysiological recordings, computational models for understanding reconfiguration mechanisms; * standardized methods to store and process data, in agreement with the FAIR principles. We accept submissions of manuscripts as Original Research, Systematic Review, Review (and mini-Review), Perspective, Clinical Trial, Case Report, Brief Research Report. Deadline for manuscript submission is June 5th, 2021. More information can be found here<https://www.frontiersin.org/research-topics/18352/improving-neuroprosthetics-through-novel-techniques-for-processing-electrophysiological-human-brain>. We look forward to your contributions. The Research Topic co-editors, Marianna Semprini Gabriele Arnulfo Ioannis Delis Felix Siebenhühner Gianluca Susi Marianna Semprini, PhD Rehab Technologies IIT-INAIL Lab Phone : 010 71781 212 ISTITUTO ITALIANO DI TECNOLOGIA Via Morego 30, 16163 Genova Site: www.iit.it