Applications are invited for one PhD student position at the University of Zurich/ETH Zurich. The position is funded by a SystemsX grant from the Swiss National Science Foundation. The project is entitled "Baysian learning of quantal parameters at single synapse resolution", and involves both experimentation and theory. Most models of synaptic transmission assume that all synapses between two neurons are identical. However, there is experimental evidence for significant heterogeneity in synaptic transmission between synapses. The major goal of this project is the development of an approach that allows for quantification of functional synaptic parameters incorporating single synapse heterogeneity. Half of the project will be devoted to experiments (electrophysiological and optophysiological investigation of synaptic transmission at Drosophila synapses), while the second part will involve modeling (Bayesian learning). The PhD student will be co-supervised by Prof. Martin Müller (Institute of Molecular Life Sciences, University of Zurich) and Prof. Jean-Pascal Pfister (Institute of Neuroinformatics, ETH and University of Zurich). Both institutes offer ideal environments for performing theory-driven experiments due to the presence of many theoretical and experimental labs. The candidate should hold a Master degree in Physics, Biology, Neuroscience, Computational Neuroscience or a related field. She/he should have keen interests in theory-driven experiments. Preference will be given to candidates with prior experience in an experimental lab, strong mathematical or good programming skills. The applicant should submit a CV (including contacts of two referees), a statement of research interests, marks obtained for the Master, and the abstract of the Master thesis in electronic format to Jean-Pascal Pfister (jpfister@ini.uzh.ch <mailto:jpfister@ini.uzh.ch>) or Martin Müller (Martin.Mueller@imls.uzh.ch <mailto:Martin.Mueller@imls.uzh.ch>). The position is offered for a period of three years and can be extended. The preferred starting date is January 2016. Salary scale is provided by the Swiss National Science Foundation (http://www.snf.ch/SiteCollectionDocuments/allg_doktorierende_e.pdf <http://www.snf.ch/SiteCollectionDocuments/allg_doktorierende_e.pdf>). Deadline for application is the 30th of November 2015 or until the position is filled. +++ Martin Müller SNSF Assistant Professor Institute of Molecular Life Sciences University of Zurich Y55-K78 Winterthurerstrasse 190 8057 Zurich Switzerland www.imls.uzh.ch/mueller.html <http://www.imls.uzh.ch/mueller.html> www.neuroscience.ethz.ch/research/molecular_cellular/mueller <http://www.neuroscience.ethz.ch/research/molecular_cellular/mueller> +++ Jean-Pascal Pfister SNSF Assistant Professor Theoretical Neuroscience Group Institute of Neuroinformatics University of Zurich and ETH Zurich Winterthurerstrasse 190 8057 Zurich, Switzerland www.ini.uzh.ch/~jpfister <http://www.ini.uzh.ch/~jpfister> www.neuroscience.ethz.ch/research/computation_modeling/pfister <http://www.neuroscience.ethz.ch/research/computation_modeling/pfister>