It is our pleasure to share with you a large database of whole-cell intracellular recordings from 315 neurons located in the supragranular layers (L2/3) of the primary somatosensory cortex in adult mice (9-45 weeks old) from both sexes (females, N=195; males, N=120). Data include 361 somatic current-clamp (CC) and 476 voltage-clamp (VC) experiments, recorded using a step-and-hold protocol (CC, N=257; VC, N=46), frozen noise injections (CC, N=104) and triangular voltage sweeps (VC, 10 (N=132), 50 (N=146) and 100 ms (N=152)), from regular spiking (N=169) and fast-spiking neurons (N=66).

We believe that this database will particularly benefit computational modellers, as the data can be used to systematically study the properties of somatic integration, and the principles of action potential generation across sexes and across electrically characterised neuronal classes in adulthood. Understanding the principles of the somatic transformation of postsynaptic potentials into action potentials will shed light onto the computational principles of intracellular information transfer in single neurons and information processing in neuronal networks, helping to recreate neuronal functions in artificial systems.

So feel free to use the data for your (cortical) cell models!

The data can be found here: http://gigadb.org/dataset/100535

The paper can be found here:  https://doi.org/10.1093/gigascience/giy147

Best regards and happy holidays,

Fleur Zeldenrust

Tansu Celikel