Dear colleagues,

This PhD will investigate the question "Why do some people maintain good brain health as they age, while others experience much faster decline?"

We are looking for an enthusiastic PhD student to develop multi-omics digital twins - computational models that capture an individual’s biological state, model how it changes over time, and explore how they might respond to different interventions.

The project will combine multi-omics data with computational modelling and machine learning to understand the biological processes underlying healthy and accelerated brain ageing. Where appropriate, these data will also be linked with imaging, cognitive and clinical measures.

The project will provide interdisciplinary training in multi-omics analysis, machine learning, computational modelling, and responsible health-data research, with opportunities to work across Manchester’s research communities in ageing, digital health, and data science.

The aim is to move beyond simply describing how quickly someone is ageing, towards understanding why individuals age differently and identifying biological markers of resilience and potential intervention targets.

📅 Start date: September 2027
📍 University of Manchester

If you are interested in applying or would like to find out more about the project, please get in touch or apply via this link. 

Best wishes,

Caroline