Eve Marder

Brandeis University

Cryptic (hidden) changes that result from perturbations 

and climate change shape future dynamics of degenerate neurons and circuits

Abstract:  A fundamental problem in neuroscience is understanding how the properties of individual neurons and synapses contribute to neuronal circuit dynamics and behavior.  In recent years we have done both computational and experimental studies that demonstrate that the same physiological output can arise from multiple, degenerate solutions, and that individual animals with similar behavior can nonetheless have quite different sets of underlying circuit parameters.  Most recently, we have been studying the resilience of individual animals to perturbations such as temperature and high potassium concentrations.  This has revealed that extreme environmental experiences can produce long-term changes in circuit performance that can be hidden, or “cryptic” unless the animals are again challenged or perturbed.  Our present experimental and computational work is designed to understand differential resilience in natural, wild-caught animals in response to climate change, and shows long-lasting influences of the animals’ temperature history. 

About VVTNS : Created as the World Wide Neuroscience Seminar (WWTNS) in November 2020 and renamed in homage to Carl van Vreeswijk in Memoriam (April 20, 2022), its aim is to be a platform to exchange ideas among theoreticians. Speakers have the occasion to talk about theoretical aspects of their work which cannot be discussed in a setting where the majority of the audience consists of experimentalists. The seminars, held on Wednesdays at 11 am ET,  are 45-50 min long followed by a discussion. The talks are recorded with authorization of the speaker and are available to everybody on our YouTube channel.